基因启动子甲基化与子宫内膜异位症恶性转化研究进展

子宫内膜异位症(endometriosis,EMS)是一种常见且难治的雌激素依赖性妇科疾病,影响15%的育龄妇女。其特征是子宫腔外存在功能性子宫内膜腺体和间质。EMS的恶性转化是威胁妇女生命最危险的风险之一,被认为发生在约1%的EMS病例中。EMS最常见的恶性转化部位是卵巢,这种卵巢癌被称为EMS相关卵巢癌(EMS associated ovarian cancer,EAOC)。EAOC相关的具体机制还有待阐明。异常DNA甲基化是最常被研究的表观遗传改变,与人类肿瘤的发生发展密切相关。本文将综述近年来基因启动子甲基化与EMS恶性转化间关系的研究进展。

Endometriosis(EMS)is a common and refractory estrogen-dependent gynecological disorder affecting 15%of women of reproductive age.It is characterized by the presence of functional endometrial glands and stroma outside the uterine cavity.Malignant transformation of EMS is one of the most dangerous risks to women's lives and is thought to occur in about 1%of EMS cases.The most common site of malignant transformation of EMS is the ovary,which is called EMS associated ovarian cancer(EAOC).The specific mechanism of endometriosis associated with ovarian cancer remains to be elucidated.Abnormal DNA methylation is the most commonly studied epigenetic change,which is closely related to the occurrence and development of human tumors.This paper reviews the recent research progress on the relationship between gene promoter methylation and EMS malignant transformation.