YAP蛋白的亚细胞定位在瘢痕疙瘩发生中的作用

Role of subcellular localization of YAP protein in the development of keloids

瘢痕疙瘩主要是由于皮肤修复过程中出现异常纤维化,打破了细胞外基质合成与降解的平衡,使细胞外胶原过度沉积而形成。目前瘢痕疙瘩的治疗方式以包含手术切除、局部注射、激光、放射治疗的综合治疗为主,但仍有较高的复发率。探究瘢痕疙瘩发生发展的分子机制对瘢痕疙瘩的临床治疗有重要意义。Hippo通路可能是瘢痕疙瘩发生的重要通路之一。Hippo通路下游转录调节因子YAP蛋白的亚细胞定位同瘢痕疙瘩的发生发展存在一定联系。本文对瘢痕疙瘩发生过程中Hippo通路的作用及其机制进行综述,为瘢痕疙瘩的治疗提供一定的理论支持。

Keloids are formed mainly due to abnormal fibrosis during skin repair,which breaks the balance of extracellular matrix synthesis and degradation,and causes excessive deposition of extracellular collagen.At present,the treatment of keloids is mainly based on comprehensive treatment including surgical resection,local injection,laser and radiotherapy,but there is still a high recurrence rate.Exploring the molecular mechanism of keloid occurrence and development is of great significance for the clinical treatment of keloids.Hippo pathway may be one of the important pathways that cause keloids.The subcellular localization of YAP protein as a transcriptional regulator downstream of the Hippo pathway is related to the occurrence and development of keloids.In this article,the role and mechanism of the Hippo pathway during the occurrence of keloids were reviewed in order to provide some theoretical support for the treatment of keloids.