饮食辅助治疗HIV患者的研究进展

Research Progress of Dietary Adjuvant Therapy for HIV Patients

人类免疫缺陷病毒(HIV)是造成人类免疫系统缺陷的一种病毒。HIV可异常激活免疫细胞,大量减少肠道的CD4+T淋巴细胞,导致对致病菌等的防御力减弱,使得肠道免疫功能紊乱,肠道菌群失衡,并引发其它系统异常。临床上采用抗逆转录病毒治疗(ART)的同时会伴有腹泻、恶心、过敏等不良反应。近年来有研究发现采用益生菌与ART治疗相结合的方法,可以调节肠道菌群,抑制细菌移位,降低HIV感染者的炎症系数。文章综述HIV引起肠道微生态变化后,通过补充多种益生菌辅助治疗HIV患者的功效及机制。已发表的文献研究表明:通过含益生菌的饮食辅助治疗HIV感染具有积极作用,是一种经济可行的辅助治疗方法。

Human immunodeficiency virus(HIV)is a virus that causes defects in the human immune system.HIV can abnormally activate immune cells,greatly reduce CD4+T lymphocytes in the intestine,weaken the defense against pathogenic bacteria,make intestinal immune dysfunction,imbalance of intestinal flora,and cause other system abnormalities.In clinical practice,anti retroviral therapy(ART)is accompanied by diarrhea,nausea,allergy and other adverse reactions.In recent years,studies have found that the combination of probiotics and ART treatment can regulate intestinal flora,inhibit bacterial translocation,and reduce the inflammatory coefficient of HIV infected people.This article mainly summarizes the efficacy and mechanism of adjuvant treatment of HIV patients by supplementing a variety of probiotics after the intestinal microecological changes caused by HIV.It shows that dietary adjuvant treatment of HIV infection with probiotics has a positive effect and is an economic and feasible treatment method.