慢性牙周炎患者入院时血清脂联素、瘦素水平与疾病严重程度的关系

Relationship Between Serum Adiponectin and Leptin Levels and Disease Severity in Patients with Chronic Periodontitis Upon Admission

目的探讨慢性牙周炎(CP)患者血清脂联素(ADPN)、瘦素(LEP)的表达及与疾病严重程度的关系。方法前瞻性纳入郑州大学第一附属医院2021年3月至2023年3月收治的90例CP患者为研究组,并依据入院时疾病严重程度分为轻度组(48例)、中度组(28例)、重度组(14例),另选取同期至医院体检的90例健康人群作为对照组。对比研究组与对照组、不同疾病严重程度CP患者间的血清ADPN、LEP水平及其他临床资料。结果研究组血清LEP水平高于对照组,ADPN水平低于对照组(P<0.05)。重度组、中度组、轻度组患者LEP、既往吸烟史占比依次降低,ADPN水平依次升高(P<0.05)。经点二列相关性分析显示,血清LEP与CP患者疾病严重程度呈正相关(r>0,P<0.05);血清ADPN、既往吸烟史与CP患者疾病严重程度呈负相关(r<0,P<0.05)。结论血清ADPN、LEP在CP患者中呈异常表达,且随着病情严重程度的提升,ADPN水平下降,LEP水平升高。

Objective To investigate the relationship between serum adiponectin(ADPN)and leptin(LEP)levels and disease severity in patients with chronic periodontitis(CP)upon admission.Methods A total of 90 CP patients admitted to the First Affiliated Hospital of Zhengzhou University from March 2021 to March 2023 were prospectively included as the study group,and 90 patients were divided into mild group(48 cases),moderate group(28 cases),and severe group(14 cases)according to the severity of disease at admission,and 90 healthy people who went to the hospital for physical examination at the same time were selected as the control group.The serum ADPN,LEP levels,and other clinical data between the study group and the control group were compared,as well as CP patients with different disease severity.Results The proportion of LEP and previous smoking history decreased in the severe,moderate,and mild groups,while the level of ADPN increased in turn(P<0.05).According to point two column correlation analysis,serum LEP was positively correlated with the severity of disease in CP patients(r>0,P<0.05).There was a negative correlation between serum ADPN,past smoking history,and the severity of disease in CP patients(r<0,P<0.05).Conclusion Serum ADPN and LEP are abnormally expressed in CP patients,and as the severity of the disease increases,ADPN levels decrease while LEP levels increase.