扶正逐瘀方联合2HRZE/4HR方案治疗阴虚血瘀证肺结核患者的效果

Application of Fuzheng Zhuyu Formula Combined with 2HRZE/4HR Scheme in the Treatment of Yin deficiency and Blood Stasis Syndrome in Pulmonary Tuberculosis Patients

目的探讨扶正逐瘀方联合2HRZE/4HR方案在肺结核患者阴虚血瘀证治疗中的应用效果。方法以随机数字表法将河南中医药大学第三附属医院2020年1月至2022年5月接收的肺结核患者106例分为两组,各53例。对照组接受2HRZE/4HR抗结核方案治疗,研究组接受扶正逐瘀方联合2HRZE/4HR方案治疗。比较两组疗效、痰菌转阴率、免疫功能[免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)]、不良反应发生率。结果研究组治疗总有效率较对照组高(P<0.05)。治疗3个月,研究组痰菌转阴率较对照组高(P<0.05);治疗6个月,两组痰菌转阴率差异无统计学意义(P>0.05)。治疗6个月,两组血清IgA、IgG、IgM水平均升高,且研究组较对照组高(P<0.05)。治疗期间,研究组不良反应发生率低于对照组(P<0.05)。结论扶正逐瘀方联合2HRZE/4HR方案治疗阴虚血瘀型肺结核疗效确切,可促进痰菌转阴,改善机体免疫功能,降低不良反应发生风险。

Objective To explore application efficacy of Fuzheng Zhuyu formula combined with 2HRZE/4HR scheme in treat with Yin deficiency and blood stasis syndrome in pulmonary tuberculosis patients.Methods A total of 106 pulmonary tuberculosis patients admitted to the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine from January 2020 to May 2022 were divided into two groups using a random number table method,with 53 patients in each group.The control group received treatment with 2HRZE/4HR anti tuberculosis regimen,while the study group received treatment with Fuzheng Zhuyu Formula combined with 2HRZE/4HR regimen.The efficacy,sputum bacterial conversion rate,immune function[immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM)],and incidence of adverse reactions were compared in both groups.Results The total effective rate of treatment in the study group was higher in comparison with control group(P<0.05).Compared with control group,the sputum bacteria conversion rate in the study group was higher after 3 months of treatment(P<0.05),the difference was not statistically significant in the conversion rate of sputum bacteria between the two groups after 6 months of treatment(P>0.05).After 6 months of treatment,the serum levels of IgA,IgG,and IgM in both groups increased,and compared with control group,the study group was higher(P<0.05).During the treatment period,the incidence of adverse reactions in the study group was lower than that in the control group(P<0.05).Conclusion The combination of Fuzheng Zhuyu formula and 2HRZE/4HR regimen has a definite therapeutic effect on Yin deficiency and blood stasis type pulmonary tuberculosis.It can promote the conversion of sputum bacteria to negative,improve the body's immune function,and reduce the risk of adverse reactions.