头孢唑啉中间体TDA合成方法研究

Synthesis Method of Cefazolin Intermediate

为了找出最佳工艺条件,提高产品质量和收率,在绿色环保溶剂碳酸二甲酯中,7-ACA与侧链2-巯基-5-甲基-1,3,4噻二唑(MMT)缩合生成TDA,从而提高TDA的质量和收率。结果表明:使用污染少、易回收的碳酸二甲酯作为反应溶剂,符合环保、安全生产要求,而且使TDA的重量收率由原来的90%提高到120%。该方法是合成头孢唑啉中间体适宜的工业化方法。

In order to improve the quality and yield of products by finding out the optimal technological condition,in the green environmental protection solvent dimethyl carbonate,TDA was synthesized by condensation reaction with the side chain compound 2-mercapto-5-methyl-1,3,4-thiadiazole(MMT)and 7-amino-cephalosporanic(7-ACA),so as to increase the yield and quality of TDA.The results showed that the use of dimethyl carbonate with less pollution and easy recovery as the reaction solvent was in line with the requirements of environmental protection and safety production,and the collection rate of TDA was increased from 90%to 120%.The method is an appropriate industrialized method for synthesizing cefazolin intermediates.