盐酸米诺环素软膏配合甲硝唑口腔粘贴片对牙周炎患者的治疗效果

The Effect of Minocycline Hydrochloride Ointment Combined with Metronidazole Oral Adhesive Tablets on Patients with Periodontitis

目的:分析盐酸米诺环素软膏配合甲硝唑口腔粘贴片对牙周炎患者的治疗效果。方法:选取2021年10月至2023年9月郑州市口腔医院收治的178例牙周炎患者,按照随机分组原则分为对照组和观察组,各89例。对照组采用甲硝唑口腔粘贴片治疗,观察组在对照组的治疗方案上采用盐酸米诺环素软膏治疗。比较两组患者牙周指数及牙周袋深度(PD)、龈沟液炎症因子、临床疗效。结果:观察组患者临床总有效率高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组患者牙龈指数(GI)、菌斑指数(PLI)、龈沟出血指数(SBI)、PD均低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组患者龈沟液白细胞介素(IL)-6、IL-1β、基质金属蛋白酶(MMP)-8水平低于对照组,差异具有统计学意义(P<0.05)。结论:盐酸米诺环素软膏配合甲硝唑口腔粘贴片治疗牙周炎,可明显减轻牙龈炎症反应,改善牙周病理状态。

Objective To analyze the therapeutic effect of minocycline hydrochloride ointment combined with metronidazole oral adhesive tablets on patients with periodontitis.Methods A total of 178 patients with periodontitis admitted to Zhengzhou Stomatological Hospital from October 2021 to September 2023 were selected and divided into a control group and an observation group according to the principle of random grouping,with 89 cases in each group.The control group was treated with metronidazole oral adhesive tablets,and the observation group was treated with minocycline hydrochloride ointment on the treatment plan of the control group.Periodontal index,periodontal pocket depth(PD),gingival crevicular fluid inflammatory factors and clinical efficacy were compared between the two groups.Results The total clinical effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,gingival index(GI),plaque index(PLI),sulcus bleeding index(SBI)and PD in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of gingival crevicular fluid interleukin(IL)-6,IL-1β and matrix metalloproteinase(MMP)-8 in the observation group were lower than those in the control group,with statistical significance(P<0.05).Conclusion Minocycline hydrochloride ointment combined with metronidazole oral adhesive tablet has achieved ideal effect in the treatment of periodontitis,which can significantly reduce gingival inflammation and improve periodontal pathologic status.