卵巢交界性Brenner瘤2例并文献复习

Ovarian borderline Brenner tumors:a clinicopathological study and literature review of 2 cases

目的探讨卵巢交界性Brenner瘤的临床病理特征、诊断和鉴别诊断。方法回顾性分析2例卵巢交界性Brenner瘤的病理学特点并复习相关文献。结果患者年龄分别为49岁、66岁,临床表现主要为盆腔包块,肿块呈实性及囊实性,镜下囊壁内衬上皮细胞,实性区见大小形态各异的移行细胞巢,细胞巢排列紧密,可见不规则分支,或类似尿路上皮肿瘤的乳头状结构,但无间质浸润,有核不典型性,可伴黏液性上皮化生,可见良性Brenner瘤成分。结论交界性Brenner瘤是一种少见的卵巢上皮性肿瘤,预后良好,诊断主要根据组织病理学和免疫组化标记,须多取材排除恶性。手术切除肿瘤是主要的治疗手段。

Objective To investigate the clinicopathological features,diagnosis and differential diagnosis of borderline Brenner tumor of ovary.Methods The pathological features of 2 cases of borderline Brenner tumor of ovaiy were retrospectively analyzed and related literature was reviewed.Results The patients were 49 and 66 years old respectively.The main clinical manifestations were pelvic mass,The masses were solid,solid and partly cystic lesion.Microscopically;the capsule wall was lined with epithelial cells.In the solid area,transitional cell nests of different sizes were found,which were closely arranged,with irregular branches or papillary structures similar to urothelial tumors,but without stromal infiltration.Borderline Brenner tumor has nuclear atypia and may be accompanied by mucinous metaplasia.Conclusion Borderline Brenner tumor is a rare epithelial ovarian tumor with a good prognosis.The diagnosis is mainly based on histopathological and immunohistochemical markers.Surgical removal of the tumor is the main treatment.