甲状旁腺激素(1-34)对老年股骨颈骨折合并骨质疏松症患者的疗效

Efficacy of Parathyroid Hormone(1-34)in Elderly Patients with Femoral Neck Fracture Combined with Osteoporosis

目的:探究甲状旁腺激素(1-34)联合空心钉在老年股骨颈骨折合并骨质疏松症患者中的临床疗效。方法:选取2020年7月至2021年7月济源市人民医院收治的老年股骨颈骨折合并骨质疏松症患者80例,随机分为观察组和对照组,各40例。对照组患者给予空心钉治疗,观察组患者采用甲状旁腺激素(1-34)联合空心钉治疗。观察并比较两组患者骨折愈合时间、出院时间、疼痛评分、髋关节功能评分、骨密度水平及生活质量评分。结果:观察组患者骨折愈合时间、出院时间短于对照组,疼痛评分低于对照组,髋关节功能评分及骨密度水平高于对照组,差异均具有统计学意义(P<0.05)。结论:甲状旁腺激素(1-34)联合空心钉治疗方案应用于老年股骨颈骨折合并骨质疏松症患者可获得较好的临床疗效,相较于单用空心钉治疗,患者康复的时间更短,治疗后疼痛症状缓解显著,髋关节功能及骨密度水平改善效果好。

Objective To explore the clinical efficacy of parathyroid hormone(1-34)combined with hollow nail in elderly patients with femoral neck fracture combined with osteoporosis.Methods A total of 80 elderly patients with femoral neck fracture combined with osteoporosis admitted to Jiyuan People's Hospital from July 2020 to July 2021 were randomly divided into an observation group and a control group,with 40 patients in each group.The control group was treated with hollow nailing,and the observation group was treated with parathyroid hormone(1-34)combined with hollow nailing.Fracture healing time,discharge time,pain score,hip function score,bone density level and quality of life score were observed and compared between the two groups.Results Fracture healing time and discharge time in the observation group were shorter than that of the control group,pain score was lower than that of the control group,hip function score and bone mineral density level were higher than that of the control group,the differences were statistically significant(P<0.05).Conclusion Parathyroid hormone(1-34)combined with hollow nail therapy can obtain better clinical efficacy in elderly patients with femoral neck fracture complicated with osteoporosis.Compared with hollow nail therapy alone,the recovery time of patients is shorter,the pain symptoms are significantly relieved after treatment,and the hip function and bone mineral density level are improved.