氟康唑联合克霉唑阴道栓治疗霉菌性阴道炎的效果及对临床症状改善的影响

Effect of Fluconazole Combined with Clotrimazole Vaginal Suppository in the Treatment of Fungal Vaginitis and its Effect on the Improvement of Clinical Symptoms

目的研究氟康唑联合克霉唑阴道栓治疗霉菌性阴道炎的效果及对临床症状改善的影响。方法选取2020年4月-2022年4月我院诊治的68例霉菌性阴道炎患者为研究对象,采用随机数字表法分为对照组和观察组,各组34例。对照组采用克霉唑阴道栓,观察组在对照组基础上联合氟康唑治疗,比较两组临床疗效、临床症状评分、临床症状消失时间、不良反应发生率、复发率。结果观察组治疗总有效率为91.18%,高于对照组的79.41%(P<0.05);两组治疗后临床症状评分均低于治疗前,且观察组低于对照组(P<0.05);观察组排尿痛、白带异常、外阴瘙痒、外阴红肿消失时间均短于对照组(P<0.05);观察组不良反应发生率与对照组比较,差异无统计学意义(P>0.05);随访3、6个月,观察组复发率均低于对照组(P<0.05)。结论氟康唑联合克霉唑阴道栓治疗霉菌性阴道炎的疗效确切,可减轻临床症状,缩短临床症状消失时间,降低复发率,且不会增加临床不良反应,是一种有效、可行、安全的治疗方案。

Objective To study the effect of fluconazole combined with clotrimazole vaginal suppository in the treatment of fungal vaginitis and its effect on the improvement of clinical symptoms.Methods A total of 68 patients with mycotic vaginitis diagnosed and treated in our hospital from April 2020 to April 2022 were selected as the research objects.They were divided into control group and observation group by random number table method,with 34 patients in each group.The control group was treated with clotrimazole vaginal suppository,and the observation group was treated with fluconazole on the basis of the control group.The clinical efficacy,clinical symptom score,disappearance time of clinical symptoms,incidence of adverse reactions and recurrence rate were compared between the two groups.Results The total effective rate of treatment in the observation group was 91.18%,which was higher than 79.41%in the control group(P<0.05).The clinical symptom scores of the two groups after treatment were lower than those before treatment,and the observation group was lower than the control group(P<0.05).The disappearance time of urination pain,leucorrhea abnormality,vulva pruritus and vulva swelling in the observation group was shorter than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).After 3 and 6 months of follow-up,the recurrence rate of the observation group was lower than that of the control group(P<0.05).Conclusion Fluconazole combined with clotrimazole vaginal suppository is effective in the treatment of fungal vaginitis.It can reduce clinical symptoms,shorten the disappearance time of clinical symptoms,reduce the recurrence rate,and will not increase clinical adverse reactions,which is an effective,feasible and safe treatment.