质子泵抑制剂联合铝镁加混悬液治疗胃内镜黏膜溃疡的临床价值

Clinical Value of Proton Pump Inhibitor Combined with Aluminum Magnesium Suspension in the Treatment of Gastric Endoscopic Mucosal Ulcer

目的研究质子泵抑制剂联合铝镁加混悬液治疗胃内镜黏膜溃疡的疗效。方法选取2021年1月-2022年12月我院诊治的80例胃内镜黏膜溃疡患者为研究对象,采用随机数字表法分为对照组和观察组,各40例。对照组采用质子泵抑制剂治疗,观察组在对照组基础上联合铝镁加混悬液治疗,比较两组临床疗效、延迟性出血发生率、溃疡面积、消化道症状评分(GSRS)、不良反应发生率。结果观察组治疗总有效率为95.00%,高于对照组的80.00%(P<0.05);观察组延迟性出血发生率为5.00%,低于对照组的12.50%(P<0.05);观察组治疗2、4周后溃疡面积小于对照组,GSRS评分低于对照组(P<0.05);观察组不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论质子泵抑制剂联合铝镁加混悬液可提高胃内镜黏膜溃疡的治疗效果,减轻胃肠道症状,降低延迟性出血发生率,缩小溃疡面积,且不会增加不良反应,应用安全性较高。

Objective To study the effect of proton pump inhibitor combined with aluminum magnesium suspension in the treatment of gastric endoscopic mucosal ulcer.Methods A total of 80 patients with gastric endoscopic mucosal ulcer diagnosed and treated in our hospital from January 2021 to December 2022 were selected as the research objects.They were divided into control group and observation group by random number table method,with 40 patients in each group.The control group was treated with proton pump inhibitors,and the observation group was treated with aluminum magnesium plus suspension on the basis of the control group.The clinical efficacy,incidence of delayed bleeding,ulcer area,gastrointestinal symptom score(GSRS),and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.00%,which was higher than 80.00%in the control group(P<0.05).The incidence of delayed bleeding in the observation group was 5.00%,which was lower than 12.50%in the control group(P<0.05).After 2 and 4 weeks of treatment,the ulcer area of the observation group was smaller than that of the control group,and the GSRS score was lower than that of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion Proton pump inhibitor combined with aluminum magnesium suspension can improve the therapeutic effect of gastric endoscopic mucosal ulcer,reduce gastrointestinal symptoms,the incidence of delayed bleeding and the ulcer area,and will not increase adverse reactions,the application safety is high.