基于“伏邪理论”探讨CAC发病中TAMs/MUC1介导的结肠炎性微环境形成机制

Formation Mechanism of Colonic Inflammatory Microenvironment Mediated byTAMs/MUC1 in CAC Based on the‘Theory of Latent Pathogen’

炎性微环境在结肠“炎-癌”转化的过程中发挥着关键作用,其介导的结肠“炎-癌”转化过程与中医“伏邪理论”具有相似性。本文基于“伏邪理论”探讨了肿瘤相关巨噬细胞(TAMs)与黏蛋白1(MUC1)之间的交互关系介导的结肠炎性微环境形成机制,认为异常表达的MUC1可作为“伏痰”的研究指标,进一步提出在临床早期治疗结肠炎相关结直肠癌(CAC)时,应以扶正透邪为基本原则,灵活运用健脾化痰、调气化痰、清温消痰、活血解毒化痰等治法,以有效干预结肠炎的恶性转化。

Inflammatory microenvironment plays a crucial role in the process of“inflammation-cancer”transformation of colon.The transformation process mediated by the inflammatory microenvironment is similar to the theory of‘Latent pathogen’in traditional Chinese medicine(TCM).Based on the theory of‘Latent pathogen’,this paper explores the mechanism of colonic inflammatory microenvironment formation mediated by the relationship between TAMs and MUC1,and we believe that abnormal expression of MUC1 could be used as an indicator for the study of“latent phlegm”.It is also suggested that in the clinical prevention and treatment of colitis-associated colorectal cancer(CAC),the basic principle should be outthrusting the pathogen.Furthermore,flexibly applying such treatment methods as fortifying spleen and resolving phlegm,regulating qi,clearing warm pathogen,and promoting blood circulation and detoxification is also helpful.