青少年子宫内膜异位症药物治疗选择及药物治疗进展

Drug treatment options and research progress of adolescent endometriosis

子宫内膜异位症是一种慢性、复发性疾病,需要进行长期管理。青少年内异症是不容忽视的一个群体,药物治疗是其长期管理及保留生育力的重要方法。治疗子宫内膜异位症的药物有很多种,如非甾体抗炎药、复方口服避孕药、孕激素、促性腺激素释放激素激动剂(GnRHa)。在药物治疗选择上需要考虑青少年的特点,个体化治疗。为了更好地进行长期管理,需要开发出新的治疗药物,以有效缓解子宫内膜异位症而不会损伤生育力。本文主要综述了青少年子宫内膜异位症药物治疗选择及基础药物治疗的研究进展,期望延缓疾病进展降低不良反应保留生育力,以提高患者的生活质量,减少不良结局。

Endometriosis is a chronic,relapsing disease that requires long-term management.Adolescent endometriosis is a group that can be ignored,and the drug treatment is an important method for long-term management and fertility preservation.There are many kinds of drugs to treat endometriosis,such as NSAIDs,combined oral contraceptives(COC),progesterone,GnRHa.For the drug treatment selection,the characteristics of adolescents should be carefully considered and individualized treatment should be provided.In order to better long-term management,it is necessary to develop new treatments,which can effectively relieve endometriosis without damaging fertility.This review focuses on the drug treatment options and research progress of basic drug treatment for adolescent endometriosis,so as to delay disease progression,reduce adverse reactions,preserve fertility,and improve quality of life.