中西药药动学相互作用研究方法回顾与展望

Retrospect and prospect of research methodology for pharmacokinetic interactions between traditional Chinese and western medicine

中药与化学药的联用可能改变药物的吸收、分布、代谢、排泄过程,引起中西药药动学相互作用,导致药物的药效和不良反应的改变。当前中药的药物相互作用研究方法主要参考了化学药的研究体系,但这些方法是否适用于具有多组分多靶点作用特征的中药仍未可知。通过对化学药的药物相互作用研究方法及其适用条件进行总结,收集并分析现有中西药药物相互作用的临床试验研究结果,探讨了中药药物相互作用体内外不相关的原因,提出了中药的药物相互作用体外研究方法需根据其多组分多靶点的作用特征进行构建,并在此基础上对中药药物相互作用研究方法进行了展望。

The combination of Chinese medicine and western medicine may alter the absorption,distribution,metabolism,and excretion processes of drugs,leading to pharmacokinetic interactions between Chinese and western medicine,causing changes in drug efficacy and adverse reactions.Current approaches to indentifying drug interactions in traditional Chinese medicine mainly refer to the research methods of western medicine.However,it remains unclear whether these methods are suitable for Chinese medicine with multiple-components and targets.In this review,we summarized the research methods and applicable conditions of drug interactions of western medicine,collected and analyzed the existing clinical trial study results of drug interactions between Chinese medicine and western medicine,explored the underlying reasons for the irrelevant in vitro to in vivo correlation in drug interactions of Chinese medicine.It was suggested the in vitro research methods of Chinese medicine interaction should be constructed according to the multicomponent and multi-target characteristics,and the research methods of Chinese medicine interaction were prospected on this basis.