中药活性成分通过调节m6A甲基化修饰抗肿瘤的研究进展

Advances in anti-cancer research of active ingredients of traditional Chinese medicine through regulation of m6A methylation modification

作为mRNA最常见的内部修饰,m6A富含于许多哺乳动物、植物中,影响RNA的加工、转运、翻译及降解。目前对m6A RNA甲基化研究方法的扩展及对其机制的深入挖掘使其有希望成为预防和检测肿瘤发生的生物标志物。越来越多的研究表明,中药在肿瘤的治疗中具有多靶点、效果显著、不良反应小等优势,且在该方面取得了一定进展。为总结中药活性成分通过调节m6A修饰发挥抗癌作用的机制,简述了m6A修饰相关蛋白的分类及其功能,回顾了中药活性成分通过调节m6A甲基化修饰抗癌的研究进展及其在癌症中的治疗前景。旨在进一步对抗肿瘤的发病机制加深认识,为中药通过调控m6A修饰发挥抗肿瘤作用提供思路。

As the most common internal modification of mRNA,m6A is enriched in many mammals and plants,which affects RNA processing,translocation,translation,and degradation.The current expansion of research methods on m6A RNA methylation and the in-depth excavation of its mechanism make it promising as a biomarker for the prevention and detection of tumorigenesis.More and more studies have shown that traditional Chinese medicine has the advantages of multi-targeting,significant effect and little adverse reaction in the treatment of tumors,and some progress has been made in this area.In order to summarize the mechanism of anticancer effects of active ingredients of traditional Chinese medicine through regulating m6A modification,this review is divided into two parts,the first part briefly describes the classification of m6A modification-related proteins and their functions,and the second part summarizes the research progress of anticancer of active ingredients of traditional Chinese medicine through regulating m6A methylation modification and its therapeutic prospect in cancer.The aim is to further deepen the understanding of the pathogenesis of antitumor and to provide ideas for TCM to exert antitumor effects by regulating m6A modification.