补肾活血利水法治疗老年高血压合并轻度认知障碍临床观察

Efficacy observation of method of tonifying kidney,promoting blood circulation and promoting diuresis on senile hypertension complicated with mild cognitive impairment

目的:观察补肾活血利水法治疗老年高血压合并轻度认知障碍患者的临床疗效。方法:选取老年高血压合并轻度认知障碍患者80例,按照随机数字表法分为两组各40例,对照组予以规范化降压药物治疗,治疗组在对照组基础上加用补肾活血利水方。治疗8周后分析比较两组患者治疗前后血压、24小时平均收缩压、舒张压、24小时收缩压标准差、舒张压标准差、简易精神状态量表(MMSE)、蒙特利尔认知评估量表(MoCA)评分以及尿微量白蛋白(UMAL)水平,并记录两组不良反应发生情况。结果:治疗后,治疗组总有效率92.5%,对照组总有效率77.5%(P﹤0.05);治疗后两组血压、24小时动态血压以及UMAL水平降低,MMSE、MoCA评分升高,以治疗组更明显(P﹤0.05)。结论:补肾活血利水法对老年高血压合并轻度认知障碍患者临床疗效确切,且无明显不良反应。

Objective:To observe the clinical efficacy of method of tonifying kidney,promoting blood circulation and promoting diuresis on senile hypertension complicated with mild cognitive impairment.Methods:80 cases of senile patients with hypertension complicated with mild cognitive impairment were selected and randomly divided into two groups,40 cases in each group.The control group was treated with standardized antihypertensive drugs,while the treatment group was treated plus with Bushen Huoxue Lishui formula on the basis of control group.After 8 weeks of treatment,blood pressure,24-hour mean systolic blood pressure and diastolic blood pressure,standard deviations of 24-hour systolic blood pressure and diastolic blood pressure,scores of Mini-Mental State Examination(MMSE)and Montreal Cognitive Assessment(MoCA)and urinary microalbumin(UMAL)level of patients were analyzed and compared between two groups before and after treatment,and the adverse reactions of two groups were recorded.Results:After treatment,the total effective rate was 92.5%in the treatment group and 77.5%in the control group(P﹤0.05).After treatment in two groups,blood pressure,24-hour ambulatory blood pressure and UMAL level were decreased,while the scores of MMSE and MoCA were increased,which was more obvious especially in the treatment group(P﹤0.05).Conclusion:The clinical efficacy of method of tonifying kidney,promoting blood circulation and promoting diuresis on senile hypertension complicated with mild cognitive impairment is definite,and there is no obvious adverse reaction.