骨膜蛋白在肿瘤微环境中的作用研究进展

Advances on the Function of POSTN in Tumor Microenvironment

肿瘤微环境对肿瘤的发展起重要作用,而肿瘤微环境中的细胞外基质蛋白在肿瘤细胞增殖、转移、免疫逃逸及对化疗的耐药等生物特性调节中发挥着关键作用。充分理解肿瘤微环境中各分子相互作用机制并及时给予有效的干预措施,有助于探索新的治疗靶点并抑制肿瘤进展。近期研究表明,骨膜蛋白(periostin,POSTN)作为细胞外基质蛋白中的一种重要成分,参与了多种肿瘤的生物学过程,并与肿瘤微环境中多个环节相关。从肿瘤微环境出发,总结了骨膜蛋白在肿瘤发生发展中的最新研究进展,以探讨骨膜蛋白能否成为潜在的肿瘤治疗靶点。

Tumor microenvironment has been recognized as an important part of tumor development.Extracellular matrix proteins present in tumor microenvironment play key roles in biological regulation of tumor cells such as unlimited proliferation,metasta‐sis,immune escape and drug resistance to chemotherapy.Fully understanding the molecular interaction mechanism in the tumor microenvironment and giving effective intervention measures in time would help to explore new therapeutic targets and inhibit tu‐mor progression.According to recent research,periostin(POSTN),one of extracellular matrix proteins,interacts with numerous components of the tumor microenvironment and is also involved in the biological processes of many malignancies.In order to de‐termine the possibility of POSTN as a therapeutic target,this review presented the recent findings about the involvement of POSTN in the incidence and development of malignancies from the viewpoint of the tumor microenvironment.