摘要
Aims:Metabolic dysfunction-associated fatty liver disease(MAFLD)has become a serious public health challenge and is a cause of liver cancer.Reports on the global epidemiology of MAFLD-related liver cancer remain limited.This study aimed to estimate the global burden trends of MAFLD-related liver cancer between 1990 and 2019.Methods:We estimated the numbers of global incident cases,deaths,and disability-adjusted life years(DALYs)of MAFLD-related liver cancer by analyzing data from the Global Burden of Disease Study 2019.We also analyzed the trends and regional and national differentials of MAFLD-related liver cancer.Finally,we investigated the influential factors for the trends in MAFLD-related liver cancer.Results:Globally,there were 36,340(95% uncertainty interval[UI]:29,490–44,860)incident cases,34,730(95%UI:28,390-43,180)deaths,and 795,810(95%UI:657,290–975,790)DALYs of MAFLD-related liver cancer in 2019,representing increases of 205%,195%,and 166%compared with 1990,respectively.The age-standardized incidence,mortality,and DALY rates per 100,000 population in 2019 were 0.44,0.43,and 9.64,respectively.The most pronounced increases in incidence,deaths,and DALYs were consistently observed in countries with a high sociodemographic index.Increasing trends were noted in these three measures since 2005,and the trends were much greater in men than in women.Conclusions:MAFLD-related liver cancer poses a substantial global burden that continues to grow.Undesirable trends were observed in countries with a high sociodemographic index.
