类器官模型在前列腺癌研究与治疗中的应用

Application of organoid model in prostate cancer research and treatment

前列腺癌(prostate cancer,PCa)是男性常见恶性肿瘤之一,由于其高度异质性及耐药性,一般治疗无法使患者获得最大收益。啮齿类动物与人的前列腺发育有较大区别,现有2维模型无法重现PCa患者特性,而类器官体外模型的出现,为PCa研究提供新思路,架起2维培养与体内模型之间的桥梁。该文介绍现有的前列腺模型,包括2维细胞系模型,患者来源的异种移植模型(来源系患者、循环肿瘤细胞、诱导多能干细胞的类器官模型)以及患者来源的异种移植的类器官模型,概述其在应用中的优势以及不足之处。

Prostate cancer(PCa)is one of the most common malignancies in men,and due to its high heterogeneity and drug resistance,general treatment cannot provide maximum benefit to patients..The prostate development of rodents is quite different from that of human.The existing 2 dimensional model cannot reproduce the unique characteristics of PCa patients.The appearance of in vitro organoid model provides a new idea for PCa research,and bridges the gap between 2 dimensional culture and in vivo model.This paper reviewed describes some existing prostate models,including 2 dimensional cell line models,patient-derived xenotransplantation models(organoid models derived from patients,circulating tumor cell,induced pluripotent stem cells)and organoid models derived from patient-derived xenotransplantation,outlined their advantages and disadvantages in the application.