肝细胞癌术后复发危险因素的分析

Analysis of risk factors of recurrence of hepatocellular carcinoma after operation

目的探讨肝细胞癌切除术后复发的危险因素。方法回顾性分析我院2016年4月至2018年12月收治的132例肝细胞癌切除术后的患者的临床病例资料,分析影响肝细胞癌术后复发的相关因素,单因素分析行χ^(2)检验,多因素分析采用二分类logistics回归分析。结果132例肝细胞癌术后患者复发69例,单因素分析表明:术前AFP水平、肝硬化、肿瘤数目、MVI、肿瘤包膜、肿瘤分化程度、术前焦虑、抑郁状态与肝细胞癌术后复发相关;多因素分析提示:术前AFP≥100μg/L、肝硬化、MVI、肿瘤包膜不完整、术前焦虑、抑郁状态是肝细胞癌术后复发的独立危险因素。结论术前AFP水平、肝硬化、MVI、肿瘤包膜不完整、术前焦虑、抑郁状态是肝细胞癌术后复发的重要因素。

Objective To explore the risk factors of recurrence of hepatocellular carcinoma(HCC)after surgical resection.Methods The clinical data of 132 patients with HCC after surgical resection from April 2016 to December 2018 in our hospital were analyzed retrospectively.Univariate analysis was performed usingχ^(2) test,and multivariate analysis was performed using binary logistic regression analysis to identify the risk factors of HCC recurrence after surgical resection.Results Of the 132 patients undergoing surgical resection,69 had recurrence of HCC after the operation.Univariate analysis showed that preoperative a-fetoprotein(AFP)level,cirrhosis,tumor number,microvascular invasion(MVI),tumor capsule,degree of tumor differentiation,preoperative anxiety and depression were related to HCC recurrence after surgical resection.Multivariate analysis showed that preoperative AFP≥100μg/L,cirrhosis,MVI,ncomplete tumor capsule preoperative anxiety and depression were independent risk factor for HCC recurrence after surgical resection.Conclusion Preoperative AFP level,cirrhosis,MVI,ncomplete tumor capsule preoperative anxiety and depression were independent risk factor for HCC recurrence after surgical resection.