摘要
目的 分析缬沙坦联合氨氯地平治疗社区高血压并糖尿病患者的疗效。方法 该研究共纳入82例研究对象,均是2021年5月至2023年5月医院收治的社区高血压并糖尿病患者,使用随机数字表法进行分组,分为对照组(氨氯地平治疗,41例)与研究组(缬沙坦+氨氯地平治疗,41例)。对比两组的血压指标、血糖指标、肾功能、血管内皮功能、临床疗效及不良反应。结果治疗前,两组血压指标、血糖指标、肾功能指标、血管内皮功能对比差异无统计学意义(P均> 0.05);治疗后,两组的舒张压与收缩压水平均下降,且研究组低于对照组;研究组空腹血糖、餐后2 h血糖及糖化血红蛋白水平比对照组低;两组患者的24 h尿蛋白定量、尿白蛋白排泄率及尿素氮均下降,且研究组低于对照组;与对照组相比,研究组内皮素-1更低,一氧化氮及血管内皮生长因子水平更高;研究组临床疗效高于对照组;研究组不良反应发生率低于对照组(P均<0.05)。结论 缬沙坦+氨氯地平用于社区高血压并糖尿病患者的效果良好,有利于降低血压及血糖水平,改善肾功能与血管内皮功能,减少不良反应的发生。
Objective To analyze the efficacy of valsartan combined with amlodipine in community patients with hypertension and diabetes.Methods A total of 82 study subjects were included in the study,all of whom were community hypertension and diabetes patients admitted to the hospital from 2021.0 May 2023 to 2023 May.They were grouped by random number table and divided into the control group(amlodipine treatment,n=41)and the study group(valsartan+amlodipine treatment,n=41).Comparing the blood pressure index,blood glucose index,renal function,vascular endothelial function,clinical efficacy and adverse effects of the two groups.Results Before treatment,there was no statistically significant difference in blood pressure,blood glucose,renal function,and vascular endothelial function between the two groups(all P>0.05);after treatment,diastolic blood pressure and systolic blood pressure decreased in the two groups,and the study group was lower than the control group;fasting blood glucose,postprandial blood glucose,and glycated hemoglobin levels were lower in the study group than in the control group;the 24 h urinary protein quota,urinary albumin excretion rate,and urea nitrogen decreased in both groups,and the study group was lower than the control group;the clinical efficacy of the research group was higher than the control group;and The 24 h urine protein quantification,urine albumin excretion rate and urea nitrogen decreased in the study group,and the study group was lower than the control group;compared with the control group,the study group had lower endothelin-1 and higher levels of nitric oxide and vascular endothelial growth factor;the study group had a higher clinical efficacy than the control group.The incidence of adverse reactions was lower in the study group than in the control group(all P<0.05).Conclusions Valsartan+amlodipine has good results in community patients with hypertension and diabetes,which is conducive to reducing blood pressure and blood glucose level,improving renal function and vascular endothelial function,and reducing the occurrence of adverse reactions.
作者
刘国才
LIU Guocai(Department of Family Medicine,Xinjiekou Community Health Center,Xicheng District,Beijing 100034,China)
出处
《中国医药指南》
2024年第10期67-70,共4页
Guide of China Medicine
关键词
社区高血压并糖尿病
缬沙坦
氨氯地平
血压指标
Community hypertension and diabetes mellitus
Valsartan
Amlodipine
Blood pressure index