坦度螺酮对精神分裂症患者认知功能的影响

Effects of Tandospirone on Cognitive Function in Patients with Schizophrenia

目的 分析坦度螺酮对精神分裂症患者认知功能的影响。方法 选取2021年5月至2022年12月在惠州市第二人民医院接受治疗的精神分裂症患者200例作为研究对象。所有患者入组后均接受枸橼酸坦度螺酮胶囊治疗,口服,每日3次,每次剂量10~20 mg,治疗周期为12周。比较治疗前、治疗6周和治疗12周,患者的情绪状态、认知功能障碍和临床疗效改善情况,以及治疗期间的不良反应发生情况。结果 治疗6周、12周,患者的正性情绪评分均高于治疗前,负性情绪评分均低于治疗前(P <0.05);情绪状态(RBANS)、临床疗效(CGI)均较治疗前改善(P <0.05)。治疗期间,共9例出现体重增加,10例出现倦怠感症状,7例出现嗜睡表现,8例存在胃肠不适症状,不良反应发生率为17.50%。结论 坦度螺酮应用于精神分裂症患者的临床治疗中,可以有效改善其负性情绪和认知功能,且疗效较好、安全性高。

Objective To analyze the effect of tandospirone on cognitive function in patients with schizophrenia.Methods Two hundred patients with schizophrenia who received treatment at the Second People's Hospital of Huizhou City from May 2021 to December 2022 were selected as study subjects.All patients were treated with tandospirone citrate capsules after enrollment,which were taken orally three times a day at a dose of 10-20 mg each time,and the treatment cycle was 12 weeks.The patients'mood status,cognitive dysfunction and clinical efficacy improvement,as well as the occurrence of adverse reactions during the treatment period,were compared before treatment,6 weeks and 12 weeks of treatment.Results At 6 and 12 weeks of treatment,the patients'positive mood scores were higher and negative mood scores were lower than before treatment(P<0.05);mood state(RBANS)and clinical efficacy(CGI)improved compared with before treatment(P<0.05).During the treatment period,a total of 9 cases showed weight gain,10 cases showed symptoms of lethargy,7 cases showed drowsiness,8 cases had gastrointestinal symptoms,and the incidence of adverse reactions was 17.50%.Conclusions Tandospirone applied in the clinical treatment of patients with schizophrenia can effectively improve their negative emotions and cognitive function,and the efficacy is better and safe.