视神经脊髓炎谱系疾病31例临床特点分析

Analysis of clinical characteristics of 31 cases with neuromyelitis optica spectrum disorders

目的分析水通道蛋白4-免疫球蛋白G(AQP4-IgG)阳性与AQP4-IgG阴性的视神经脊髓炎谱系疾病(NMOSD)在临床特点的差异。方法收集就诊于郑州市第九人民医院、河南中医药大学第一附属医院确诊NMOSD 31例患者临床资料,根据AQP4-IgG结果分为AQP4-IgG阳性组(23例)和AQP4-IgG阴性组(8例)。结果两组患者均是女性居多,差异无统计学意义(P>0.05);两组在起病前有无诱因方面比较,差异无统计学意义(P>0.05);AQP4-IgG阳性组合并自身免疫性疾病发生率高于AQP4-IgG阴性组,差异有统计学意义(P<0.05)。结论NMOSD患者中女性居多,AQP4-IgG阳性患者居多,AQP4-IgG阳性组与阴性组在性别分布方面均是女性居多,AQP4-IgG阳性NMOSD患者合并自身免疫性疾病发生率均高于AQP4-IgG阴性NMOSD患者,两组在起病前有无诱因、性别分布方面均无差异。

Objective To analyze the differences of clinical symptoms and characteristics between aquaporin 4-immunoglobulin G(AQP4-IgG)positive and AQP4-IgG negative neuromyelitis optica spectrum disorder(NMOSD).Methods The clinical data of 31 patients with confirmed NMOSD in Zhengzhou Ninth People′s Hospital and the First Affiliated Hospital of Henan University of Traditional Chinese Medicine were collected.According to AQP4-IgG results,the patients were divided into AQP4-IgG positive and AQP4-IgG negative groups,including 23 cases in AQP4-IgG positive group and eight cases in AQP4-IgG negative group.Results Most of the patients in the two groups were women,and the difference was not statistically significant(P>0.05).There was no significant difference in the inducement before onset between the two groups(P>0.05).The incidence of autoimmune diseases in AQP4-IgG positive group was higher than that in AQP4-IgG negative group,and the difference between the two groups was statistically significant(P<0.05).Conclusion The majority of NMOSD patients are female,the majority of AQP4-IgG positive patients.AQP4-IgG positive group and negative group are mostly female in terms of gender distribution.The incidence of autoimmune diseases in AQP4-IgG positive NMOSD patients are higher than those in AQP4-IgG negative NMOSD patients.There is no difference in the presence or absence of incentives before onset and gender distribution between the two groups.