经皮卵圆孔未闭封堵术治疗偏头痛的临床现状

Clinical status of percutaneous closure of patent foramen ovale in the treatment of migraine

卵圆孔未闭(PFO)是一种心脏解剖异常,通常胎儿在出生时未能正常关闭,导致左心室和右心室之间的血流通道仍然存在。近年来,越来越多的研究表明,PFO与偏头痛之间存在关联性,尤其是在伴有先兆的偏头痛患者之中。随着心内科介入技术的不断发展,介入封堵术已成为治疗PFO的有效方法。研究显示,通过采用封堵装置对PFO进行封堵,可以减少PFO相关的危险,如脑卒中。有研究发现,PFO封堵可能有助于减轻偏头痛发作的频率和严重程度。焦虑和抑郁是偏头痛患者常见的精神合并症。经皮PFO封堵术在减轻偏头痛症状和改善心理状况及生活质量方面也显示出良好的效果。该文还将讨论PFO封堵术的安全性和效果,以及与偏头痛相关的机制,以深入探讨这一领域的临床进展。最后,该文强调了对患者精神健康状况进行筛查和管理的必要性,并期望未来的研究能够为PFO封堵术在治疗偏头痛方面提供更为明确的指导。

A patent foramen ovale(PFO)is a cardiac anatomical abnormality that usually fails to close normally at birth,resulting in the blood flow channel between the left ventricle and the right ventricle still existing.In recent years,a growing number of studies have shown that there is a correlation between PFO and migraine,especially in migraine patients with aura.With the continuous development of interventional techniques in cardiology,interventional closure has become an effective method for the treatment of PFO.Studies have shown that the closure of PFO by using a closure device can reduce the risks associated with patent foramen ovale,such as stroke.More encouragingly,some studies have found that PFO closure may help reduce the frequency and severity of migraine attacks.Anxiety and depression are common mental complications in migraine patients.Percutaneous PFO closure has shown favorable results in alleviating migraine symptoms and improving psychological status and quality of life.This review will also discuss the safety and efficacy of PFO closure,as well as the mechanisms associated with migraine,in order to further explore the clinical advances in this field.Finally,this paper emphasize the necessity of screening and managing the mental health status of patients,and expects that future research can provide more clear guidance for PFO closure in the treatment of migraine.