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炎性相关标志物预测早期肝癌根治术后患者预后的研究进展

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摘要 原发性肝癌在中国为第四大肿瘤,同时也是导致死亡的第二大肿瘤。尽管肝癌根治术是治疗早期肝癌患者的有效方法之一,但手术本身存在较高的并发症发生风险和预后不确定性。有研究表明,炎症与肝癌的发展密切相关。长期慢性炎症可导致肝细胞的持续损伤和修复,触发肝脏再生过程,同时也增加了突变和异常细胞增殖的机会,从而导致肝癌的发生。因此,寻找快速、准确评估肝癌进展的炎性相关标志物变得至关重要。通过监测和分析这些标志物的水平变化,可及早干预疾病进展,改善疾病转归,并延长患者生存期。近年来的研究已经发现了一些潜在的早期肝癌根治术后的炎性相关标志物,包括激活的炎症细胞、炎症介质以及与肿瘤相关的炎症信号通路分子等。它们的变化反映了炎症过程中特定分子和细胞因子的变化,对于肿瘤生成、侵袭和转移等过程起着重要作用。通过了解和研究这些炎性相关标志物,医师可以更好地了解肝癌的发展情况,并及时采取干预措施,有助于改善治疗效果,延长患者的生存期。因此,寻找能够快速、准确评估肝癌进展的炎性相关标志物对于肝癌的治疗具有重要意义。本文对近年来发现的早期肝癌根治术的炎性相关标志物进行归纳,以期为临床评估早期肝癌根治术后患者预后提供更多有效依据。
作者 刘敏 李莉
出处 《癌症进展》 2024年第3期244-248,268,共6页 Oncology Progress
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