氨茶碱结合特布他林治疗稳定期慢性阻塞性肺疾病患者的临床效果及对血清PCT、TNF-α水平的影响

Clinical effect of aminophylline combined with terbutaline in the treatment of patients with stable chronic obstructive pulmonary disease and its influences on serum PCT and TNF-αlevels

目的探讨氨茶碱结合特布他林治疗稳定期慢性阻塞性肺疾病(COPD)的临床效果。方法选取2020年1月至2021年12月收治的80例稳定期COPD患者为研究对象,依据入院编号的奇偶性将其分为对照组与观察组,各40例。对照组给予常规对症及特布他林治疗,观察组在对照组基础上给予氨茶碱治疗。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))、最大通气量(MVV)及呼气峰流速(PEF)均高于对照组(P<0.05)。治疗后,观察组的白细胞介素-6(IL-6)、、C反应蛋白(CRP)、降钙素原(PCT)及肿瘤坏死因子-α(TNF-α)水平低于对照组,白细胞介素-10(IL-10)水平高于对照组(P<0.05)。治疗后,观察组的膈肌厚度、膈肌活动度、氧合指数高于对照组,二氧化碳分压(PaCO_(2))、慢性阻塞性肺疾病评估测试(CAT)评分低于对照组(P<0.05)。结论氨茶碱结合特布他林治疗稳定期COPD的临床效果理想。

Objective To investigate the clinical effect of aminophylline combined with terbutaline in the treatment of stable chronic obstructive pulmonary disease(COPD).Methods A total of 80 patients with stable COPD admitted from January 2020 to December 2021 were selected as the research objects.According to the parity of admission number,the patients were divided into control group and observation group,with 40 cases in each group.The control group was given conventional symptomatic and terbutaline treatment,and the observation group was treated with aminophylline on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the forced vital capacity(FVC),forced expiratory volume in one second(FEV_(1)),maximum ventilation volume(MVV)and peak expiratory flow rate(PEF)in the observation group were higher than those in the control group(P<0.05).After treatment,the levels of interleukin-6(IL-6),C-reactive protein(CRP),procalcitonin(PCT)and tumor necrosis factor-α(TNF-α)in the observation group were lower than those in the control group,and the level of interleukin-10(IL-10)was higher than that in the control group(P<0.05).After treatment,the diaphragm thickness,diaphragm activity and oxygenation index of the observation group were higher than those of the control group,and the arterial carbon dioxide partial pressure(PaCO_(2))and Chronic Obstructive Pulmonary Disease Assessment Test(CAT)score were lower than those of the control group(P<0.05).Conclusion The aminophylline combined with terbutaline in the treatment of stable COPD has ideal clinical effect.