乌拉地尔联合奥扎格雷钠治疗急性脑梗死的效果

Effect of urapidil combined with ozagrel sodium in the treatment of acute cerebral infarction

目的探究乌拉地尔联合奥扎格雷钠治疗急性脑梗死的效果。方法纳入2020年9月至2022年9月收治的96例急性脑梗死患者为研究对象,按随机对照双盲原则将其分为对照组和观察组,每组48例。对照组接受奥扎格雷钠治疗,观察组在对照组基础上加用乌拉地尔治疗。比较两组患者治疗前、后的血压、脑血流灌注指标、血流变指标及不良反应发生情况。结果治疗后,两组的收缩压、舒张压均下降,且观察组低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的脑血容量(CBV)、脑血流量(CBF)高于对照组,平均通过时间(MTT)短于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的血浆黏度、全血高切黏度、全血低切黏度、血细胞比容及纤维蛋白原水平均低于对照组,差异具有统计学意义(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论乌拉地尔联合奥扎格雷钠治疗急性脑梗死的效果显著,可明显改善血压、脑血流灌注指标及血流变指标,值得临床推广与应用。

Objective To investigate the effect of urapidil combined with ozagrel sodium in the treatment of acute cerebral infarction.Methods A total of 96 patients with acute cerebral infarction admitted from September 2020 to September 2022 were included as the research objects and divided into control group and observation group according to the principle of randomized controlled double-blind,with 48 cases in each group.The control group was treated with ozagrel sodium,and the observation group was treated with urapidil on the basis of the control group.Before and after treatment,the blood pressure,cerebral blood perfusion indexes,hemorheological indexes and adverse reactions were compared between the two groups.Results After treatment,the systolic blood pressure and diastolic blood pressure of both groups decreased,those in the observation group were lower than the control group,and the differences were statistically significant(P<0.05).After treatment,the cerebral blood volume(CBV)and cerebral blood flow(CBF)of the observation group were higher than those of the control group,the mean transit time(MTT)was shorter than that of the control group,and the differences were statistically significant(P<0.05).After treatment,the plasma viscosity,whole blood high tangential viscosity,whole blood low tangential viscosity,hemocytometry volume and fibrinogen level in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Urapidil combined with ozagrel sodium has a significant effect in the treatment of acute cerebral infarction,it can significantly improve blood pressure,cerebral blood perfusion indexes and hemorheological indexes,which is worthy of promotion and application in clinic.