长效胰岛素联合超短效胰岛素标准化治疗妊娠期糖尿病效果研究

Effect of Long-acting Insulin Combined with Ultra-short-acting Insulin in the Standardized Treatment of Gestational Diabetes Mellitus

目的:探究在长效胰岛素常规治疗基础上联合应用超短效胰岛素标准化治疗妊娠期糖尿病孕妇的效果。方法:随机选取2021年1月—2022年8月收治的72例妊娠期糖尿病患者,观察组(n=36),使用长效胰岛素(基础)+超短效胰岛素(饭前冲击)标准化联合治疗;对照组(n=36),使用长效胰岛素治疗妊娠期糖尿病。评估两组患者疗效指标差异。结果:治疗后,观察组患者空腹血糖(FPG)、餐后2小时血糖(2hPG)、睡前血糖以及空腹胰岛素水平均较治疗前有所下降,其中FPG、2hPG下降较明显;观察组出现羊水过多、早产、妊高症以及新生儿血糖异常等状况例数少于对照组,且不良妊娠结局发生率(22.22%)明显低于对照组(44.44%),降幅接近50%。以上结果均P<0.05,具有统计学意义。结论:长效胰岛素联合超短效胰岛素标准化治疗方法,能够降低患者血糖水平,使其处于正常血糖范围,妊娠期糖尿病孕妇不良妊娠结局发生率也大大减少。

Objective:To explore the effect of combining ultra-short-acting insulin standardized treatment on pregnant women with gestational diabetes on the basis of long-acting insulin routine treatment.Methods:A total of 72 patients with gestational diabetes mellitus admitted from January 2021 to August 2022 were randomly selected.The observation group(n=36)received standardized combined treatment with long-acting insulin(basic)and ultra-shortacting insulin(pre-meal shock).The control group(n=36)was treated with long-acting insulin for gestational diabetes.The difference of efficacy indexes between the two groups was evaluated.Results:After treatment,fasting blood glucose(FPG),2hPG(2hPG),blood glucose before going to bed and fasting insulin levels were all decreased compared with before treatment,and FPG and 2HPG were signifi cantly decreased in the observation group.The number of cases of excessive amniotic fl uid,preterm labor,pregnancy-induced hypertension and abnormal blood glucose in newborns in the observation group was less than that in the control group,and the incidence of adverse pregnancy outcome in the observation group(22.22%)was signifi cantly lower than that in the control group(44.44%),the reduction was nearly doubled.The above results were all P<0.05,with statistical signifi cance.Conclusion:The standardized treatment of long-acting insulin combined with ultra-short-acting insulin can reduce the blood glucose level of patients and make them in the normal blood glucose range,and the incidence of adverse pregnancy outcomes in pregnant women with gestational diabetes is also greatly reduced.