摘要
Pancreatic ductal adenocarcinoma(PDAC)is the leading cause of cancer-related death worldwide.As PDAC is more common in older adults and the population is aging,the incidence of pancreatic adenocarcinoma is expected to increase in the coming years.As a result,the mechanism and clinical management of PDAC in the elderly population is receiving more attention.This review will discuss age-related morphological and pathological changes,clinical management,surgery and adjuvant therapies,and molecular changes in elderly PDAC patients.More research is needed to clarify molecular mechanisms and develop new prevention and treatment strategies for PDAC in elderly patients.
基金
supported by the National Key Research and Development Program of China(2021YFA1201100)
the National Natural Science Foundation of China(grants 82072716,82030092)
Collaboration Program of Beijing,Tianjin and Hebei(grant 22JCZXJC00120)
Tianjin Research Innovation Project for Postgraduate Students(2021YJSB262).
