摘要
Precise control of circulating lipid levels is vital in both health and disease.We recently uncovered that bulk lipids,transported by lipoproteins,enter the circulation initially via the coat protein complex II(COPII)in a condensation-dependent manner.Divalent manganese,acting as a signaling messenger,selectively controls COPII condensation to regulate lipid homeostasis in vivo.Here,we present evidence for a manganese-based therapy in murine models of hypolipidemia and hyperlipidemia.
基金
The work is supported by the National Natural Science Foundation of China(NSFC:32125021,92254308,91957119,91954001,31571213 to X.W.C,32100947 to X.W.,and 62027901 to J.T.)
the National Key R&D Program(2021YFA0804802).
