Metabolic dysfunction-associated fatty liver disease and hepatocellular carcinoma:present and future

Metabolic dysfunction-associated fatty liver disease(MAFLD),previously termed non-alcoholic fatty liver disease,is one of the most common causes of chronic liver disease,affecting around 30%of the world’s adults(1).MAFLD encompasses a spectrum of liver conditions,ranging from simple steatosis to metabolic dysfunction-associated steatohepatitis(MASH),which can progress to cirrhosis and hepatocellular carcinoma(HCC)(2,3).