儿童抽动障碍围产期危险因素的Scoping分析

Risk factors for childhood tic disorders during perinatal period:a Scoping analysis

目的探讨导致儿童抽动障碍的围产期危险因素。方法对中国知网、万方数字化期刊全文数据库、PubMed和Web of Science建库至2023年3月20日的学位、期刊、会议论文进行检索,筛选出与儿童抽动障碍的围产期危险因素相关的文献,提取作者、年份、国家、研究对象、患者年龄、样本量、纳入时间、研究设计、诊断标准和危险因素进行分析。结果共检索文献307篇,其中中文85篇,英文222篇,最终纳入25篇,来自于11个国家。数据多源于精神病学、儿科学、公共健康主题期刊。诊断标准包括美国精神障碍诊断与统计手册、耶鲁综合抽动严重程度量表、国际疾病分类和中国精神障碍分类与诊断标准。结论母体自身因素是诱发儿童抽动障碍的主要风险因素,家族遗传史、孕期患有身体或心理疾病、孕期营养不良、用药等均增加发病风险。宫内发育不良、分娩意外、新生儿疾病或家庭环境不和谐也容易增加儿童抽动障碍的发病风险。

Objective To explore the risk factors associated with perinatal periods leading to childhood tic disorders.Method The degree,journal,and conference papers in China National Knowledge Infrastructure(CNKI),Wanfang Digital Journal Full-text Database,PubMed and Web of Science built up to March 20,2023 were searched to screen the literature related to perinatal periods risk factors for childhood tic disorders,extracting authors,year,country,study population,patient age,sample size,time of inclusion,study design,diagnostic criteria,and risk factors for analysis.Result A total of 307 literatures were searched,including 85 literatures in Chinese and 222 literatures in English,and 25 literatures were finally included,from 11 countries.The data mostly originated from psychiatry,pediatrics,and public health themed journals.Diagnostic criteria included the American Diagnostic and Statistical Manual of Mental Disorders,Yale Global Tic Severity Scale,International Classification of Diseases,and Chinese Classification and Diagnostic Criteria for Mental Disorders.Conclusion Maternal own factors are the main risk factors for triggering childhood tic disorders,family genetic history,physical or psychological disorders during pregnancy,malnutrition during pregnancy,and medication use increase the risk of development.Intrauterine dysplasia,delivery accidents,neonatal diseases or incompatible family environment also tend to increase the risk of childhood tic disorders.