细胞自噬对肝纤维化的影响及中医药治疗进展

The influence of autophagy on liver fibrosis and the progress of TCM treatment

自噬是细胞生长、存活及自我平衡的重要过程。自噬的失调参与多种疾病的发生、发展。依据自噬致使的降解成分到达溶酶体的途径,自噬可以分为:巨自噬、微自噬、分子伴侣介导的自噬。其中,巨自噬是目前研究较为广泛的细胞自噬形式,其在肝纤维化发生、发展中扮演着重要角色。自噬在肝纤维化中的作用取决于细胞的类型和疾病的阶段,因此通过对细胞自噬进行调控可能为逆转肝纤维化提供了新的治疗策略。数十年的研究证明,中医药治疗肝纤维化的效果突出,可提高肝纤维化逆转率。近年来,许多中药复方被报道具有调控细胞自噬改善肝纤维化的作用。因此,明确自噬对肝纤维化的意义以及中医理论对自噬和肝纤维化的认识十分重要,本文将主要阐述细胞自噬对肝纤维化的影响及中医药调控细胞自噬抗肝纤维化治疗进展。

Autophagy is an important process of cell growth,survival and homeostasis.The disorder of autophagy is in-volved in the occurrence and development of many diseases.According to the pathway by which the degradation components caused by autophagy reach the lysosomes,autophagy can be divided into macroautophagy,microautophagy and chaperon-mediated autophagy.Among them,macroautophagy is a more widely studied form of cellular autophagy,which plays an important role in the occurrence and development of liver fibrosis.The role of autophagy in liver fibrosis depends on the type of cells and the stage of the disease,so regulation of autophagy may provide a new therapeutic strategy for reversing liver fibrosis.De-cades of research has proved that traditional Chinese medicine has outstanding effects in the treatment of liver fibrosis and can im-prove the reversal rate of liver fibrosis.In recent years,many Chinese herbal compounds have been reported to regulate autophagy and improve liver fibrosis.It is important to clarify the significance of autophagy on liver fibrosis and the understanding of TCM the-ory on autophagy and liver fibrosis.This article mainly discusses the influence of autophagy on liver fibrosis and the progress of Chi-nese medicine regulation of autophagy on anti-liver fibrosis treatment.