瘦素与银屑病的研究进展

The role of leptin in psoriasis

银屑病是一种常见的免疫炎症性系统性疾病,常合并肥胖等代谢综合征。瘦素作为最经典的促炎性脂肪因子,在银屑病领域受到持续关注。目前普遍认为瘦素对银屑病起着促进作用。本文主要综述瘦素与银屑病发生发展和代谢相关合并症的关联性,以及瘦素在银屑病免疫炎症激活、表皮角质形成细胞增殖分化和促炎因子分泌、真皮乳头毛细血管增生扩张等病理过程中的可能作用机制。

Psoriasis,a systemic immune-inflammatory disease,is often associated with metabolic syndromes such as obesity.As the most classical pro-inflammatory adipokine,leptin has received persistent attention in psoriasis.Currently,it is generally believed that leptin promotes the development of psoriasis.This article delves into the intricate relationship between leptin and the development of psoriasis,along with its associated metabolic complications.Additionally,the potential mechanisms by which leptin operates in the pathological processes of psoriasis,such as immune inflammatory activation,epidermal keratinocyte proliferation,differentiation and secretion of proinflammatory factors,and proliferation and dilatation of dermal papillary capillaries,are explored.