摘要
神经发育和神经系统功能受到包括环境、遗传和表观遗传在内的多种因素的调控。N-糖基化修饰是由糖基化转移酶催化形成的蛋白质翻译后修饰,参与多种生物学过程。在神经系统中,N-糖基化修饰高丰度存在,调控神经突触的发育、成熟和胶质细胞的炎症反应。异常N-糖基化修饰与阿尔茨海默病、先天性糖基化障碍、精神分裂症和癫痫等多种神经系统疾病密切相关。本文中我们综述了N-糖基化修饰的神经细胞生物学功能及其在神经系统疾病中的作用和机制。
Neurodevelopment and neuronal function are modulated by multiple factors including environment,genetics and epigenetics.As a post-translational modification,N-glycosylation is catalyzed by glycosyltransferase and involves in diverse biological processes.N-glycosylation is abundant in neuronal system,regulates the development and maturation of synapse,and inflammatory response of glial cells.The dysregulation of N-glycosylation induces neurological disorders including Alzheimer’s disease,congenital disorders of glycosylation,schizophrenia and epilepsy.In the present review,we have summarized the progresses of N-glycosylation in regulating neuronal and astrocytic function,and its roles in neurological disorders and related mechanisms.
作者
许可星
王梦璇
李学坤
XU Ke-xing;WANG Meng-xuan;LI Xue-kun(Department of Genetics and Metabolism,Children’s Hospital,National Clinical Research Center for Child Health,School of Medicine,Zhejiang University,Hangzhou 310052,China;the Institute of Translational Medicine,School of Medicine,Zhejiang University,Hangzhou 310029,China)
出处
《解剖学报》
CAS
CSCD
2024年第2期241-246,共6页
Acta Anatomica Sinica
基金
国家自然科学基金重大研究计划培育项目(92049108)。