感染后肠易激综合征肠屏障功能损伤的研究进展

Progress in the Study of Post-Infectious Irritable Bowel Syndrome Impairment of Intestinal Barrier Function

肠易激综合征(irritable bowel syndrome,IBS)是常见的功能性胃肠病,具体的发病机制尚未能阐明。感染后肠易激综合征(post-infectious irritable bowel syndrome,PI-IBS)是其中的一个亚型。肠黏膜屏障由机械屏障、免疫屏障、化学屏障、生物屏障4个部分组成,在维持肠道稳态发挥至关重要的作用。肠黏膜屏障受损和许多疾病相关,而这一病理改变在PI-IBS中客观存在。肠屏障功能损伤机制与PI-IBS的关系有待进一步研究。文章主要从PI-IBS相关的屏障损伤的机制进行概述,为深入研究和可能的临床应用提供帮助。

Irritable bowel syndrome(IBS)is a common functional gastrointestinal disorder,the exact pathogenesis of which has not yet been elucidated.Post-infectious irritable bowel syndrome(PI-IBS)is one of the subtypes.The intestinal mucosal barrier consists of four components:mechanical,immune,chemical and biological barriers,and plays a crucial role in maintaining intestinal homeostasis.Impairment of the intestinal mucosal barrier is associated with many diseases and this pathological alteration is objectively present in PI-IBS.The relationship between the mechanisms of impairment of intestinal barrier function and PI-IBS needs to be further investigated.This article provides an overview of the mechanisms of barrier impairment associated with PI-IBS to provide an insight into further research and possible clinical applications.