脑电仿生电刺激结合醒脑开窍法对持续植物状态脑影像结构和血流量分析

Analysis of Brain Image Structure and Blood Flow in Patients with Persistent Vegetative State by EEG Biomimetic Electrical Stimulation Combined with Consciousness-Restoring and Orifice-Opening Acupuncture

目的研究脑电仿生电刺激结合醒脑开窍法对持续植物状态患者脑影像结构和血流量的影响。方法选取2019年1月—2021年1月期间于医院就诊的持续植物状态住院治疗的患者110例根据治疗方法的不同分为观察组(60例)和对照组(50例)。对照组接受脑电仿生电刺激治疗,观察组在对照组基础上联用“醒脑开窍”法促醒,两组均持续治疗30 d。治疗前后评估比较两组CRS-R,计算N-乙酰天门冬氨酸(NAA)/肌酸(Cr)和胆碱复合物(Cho)/Cr值,比较脂蛋白相关磷脂酶A2(Lp-PLA2)、总超氧化物歧化酶(T-SOD)、锰超氧化物歧化酶(Mn-SOD)、脑血容量(CBV)、脑血流量(CBF)、内皮素-1(ET-1)、血管内皮生长因子(VEGF)。结果治疗后,观察组CRS-R评分高于对照组(P<0.05)。治疗后,观察组NAA/Cr高于对照组,Cho/Cr值低于对照组(P<0.05)。治疗后,观察组Lp-PLA2低于对照组,T-SOD及Mn-SOD水平高于对照组(P<0.05)。观察组治疗后CBV和CBF水平明显高于对照组(P<0.05)。观察组治疗后NO、ET-1及VEGF水平显著优于对照组(P<0.05)。结论脑电仿生电刺激联合醒脑开窍针法可改善持续植物状态患者的意识状态、脑影像结构和血流量。

Objective To study the effects of electroencephalogram(EEG)biomimetic electrical stimulation combined with consciousness-restoring and orifice-opening acupuncture on brain image structure and blood flow in patients with persistent vegetative state.Methods A retrospective study was conducted.A total of 110 patients with persistent vegetative state admitted to the hospital from January 2019 to January 2021 were selected and divided into observation group(60 cases)and control group(50 cases)according to different treatment methods.Both groups received conventional drug treatment.The control group received EEG bionic electrical stimulation on the basis of this treatment,and the observation group was combined with consciousness-restoring and orifice-opening acupuncture on the basis of the control group to promote awakening.Both groups continued the treatment for 30 days.Before and after treatment,CRS-R scores were evaluated and compared between the two groups,and N-acetyl-aspartic acid(NAA)/creatine(Cr)and choline complex(Cho)/Cr values were analyzed and compared.The levels of lipoprotein-associated phospholipase A2(Lp-PLA2),total superoxide dismutase(T-SOD),manganese superoxide dismutase(Mn-SOD),cerebral blood volume(CBV),cerebral blood flow(CBF),endothelin-1(ET-1)and vascular endothelial growth factor(VEGF)were compared.Results After treatment,CRS-R score in the observation group was higher than that in the control group(P<0.05).After treatment,NAA/Cr in the observation group was higher than that in the control group,Cho/Cr was lower than that in the control group(P<0.05).After treatment,Lp-PLA2 in the observation group was lower than that in the control group,while the levels of T-SOD and Mn-SOD in the observation group were higher than those in the control group(P<0.05).The levels of CBV and CBF in the observation group were significantly higher than those in the control group after treatment(P<0.05).The levels of NO,ET-1 and VEGF in the observation group were significantly higher than those in the control group after treatment(P<0.05).Conclusion EEG biomimetic electrical stimulation combined with consciousness-restoring and orifice-opening acupuncture can improve the state of consciousness,brain image structure and blood flow in patients with persistent vegetative state.