炔雌醇环丙孕酮联合阿司匹林治疗多囊卵巢综合征合并复发性流产的效果分析

Effect analysis of ethoestradiol cyproterone combined with aspirin in the treatment of polycystic ovary syndrome with recurrent abortion

目的探讨多囊卵巢综合征(PCOS)合并复发性流产(RSA)采用炔雌醇环丙孕酮+阿司匹林治疗的效果。方法选80例PCOS合并RSA患者为研究对象,按照随机数字表法分对照组和研究组,每组40例。对照组采用炔雌醇环丙孕酮治疗,研究组在对照组基础上采用阿司匹林治疗,比较两组妊娠结局、性激素水平、子宫内膜情况及不良反应情况。结果研究组活产率高于对照组(P<0.05);治疗后,研究组血清促黄体生成素(LH)、睾酮(T)、卵泡刺激素(FSH)水平均低于对照组(P<0.05);治疗前两组子宫内膜厚度、内膜多层率比较,差异均无统计学意义(P>0.05);治疗后,研究组子宫内膜厚度优于对照组,内膜多层率低于对照组(P<0.05);两组不良反应总发生率比较差异无统计学意义(P>0.05)。结论炔雌醇环丙孕酮联合阿司匹林治疗PCOS+RSA效果较好,可改善患者妊娠结局,调节其性激素水平,且安全可靠,值得临床推广与应用。

Objective To investigate the effect of ethoestradiol cyproterone plus aspirin in the treatment of polycystic ovary syndrome(PCOS)complicated with recurrent abortion(RSA).Methods A total of 80 patients with PCOS and RSA were selected as the study objects,and divided into control group and study group according to random number table method,with 40 cases in each group.The control group was treated with ethoestradiol cyproterone,and the study group was treated with aspirin on the basis of the control group.The pregnancy outcomes,sex hormone levels,endometrial conditions and adverse reactions of the two groups were compared.Results The live birth rate of the study group was higher than that of the control group(P<0.05).After treatment,the levels of luteinizing hormone(LH),testosterone(T)and follicle stimulating hormone(FSH)in the study group were lower than those in the control group(P<0.05).There were no significant differences in endometrial thickness and multilayer rate between the two groups before treatment(P>0.05).After treatment,the endometrial thickness of the study group was better than that of the control group,and the rate of endometrial multilayer was lower than that of the control group(P<o.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion ethoestradiol cyproterone combined with aspirin in the treatment of PCOS+RSA is effective,can improve the pregnancy outcome of patients,regulate the level of sex hormones,and is safe and reliable,worthy of clinical promotion and application.