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Long-term antibiotic use and risk of hepatocellular carcinoma later in life: a nationwide cohort study of 9.8 million participants

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摘要 Dear Editor,Antibiotics are considered indispensable in numerous treatments against infectious diseases.However,their over-prescription and widespread use are emerging as important global issues,as they lead to resistant bacteria,reducing the efficacy of antibiotics[1].The defined daily doses per 1,000 habitants per day for antibiotics in South Korea is 28,which is much higher than the average of Organization for Economic Co-operation and Development countries[1].In animal studies,antibiotic tigecycline was found to inhibit the proliferation and induce apoptosis of hepatocellular carcinoma(HCC)cells[2].In addition,isoprenoid antibiotic was found to suppress the growth and invasion of HCC by targeting the signal transducer and activator of the transcription 3 signaling cascade[3].Despite evidence of the beneficial effects of antibiotics against HCC,evidence regarding their effects on the longterm development of HCC is limited.Introduction regarding the incidence of HCC is provided in the Supplementary file.
出处 《Cancer Communications》 SCIE 2023年第10期1174-1177,共4页 癌症通讯(英文)
基金 supported by the National Research Foundation of Korea(NRF)grant funded by the Korean government(2021R1F1A1063346) the research program of the Korea Medical Institute.Sun Jae Park received a scholarship from the BK21 FOUR education program from the National Research Foundation of Korea(NRF)。
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