他汀类药物联合β受体阻滞剂治疗慢性心力衰竭的效果分析

Effect Analysis on Statins Combined with β Receptor Blocker in Treatment of Chronic Heart Failure

目的:分析他汀类药物联合β受体阻滞剂治疗慢性心力衰竭的效果。方法:选取2021年2月—2023年2月德州市宁津县人民医院收治的慢性心力衰竭患者66例作为研究对象,随机分为研究组与对照组,各33例。对照组给予β受体阻滞剂治疗,研究组在对照组基础上采用他汀类药物治疗。比较两组治疗效果。结果:治疗前,两组左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)比较,差异无统计学意义(P>0.05);治疗后,两组LVEF高于治疗前,且研究组高于对照组,两组LVEDD、LVESD低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)水平比较,差异无统计学意义(P>0.05);治疗后,两组IL-6、hs-CRP、TNF-α水平低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。研究组治疗总有效率高于对照组,差异有统计学意义(P=0.020)。结论:他汀类药物联合β受体阻滞剂治疗慢性心力衰竭的效果显著,可改善患者心功能,降低炎性因子水平。

Objective:To analyze the effect of statins combined withβreceptor blocker in the treatment of chronic heart failure.Methods:A total of 66 patients with chronic heart failure who were admitted to Ningjin People's Hospital of Dezhou City from February 2021 to February 2023 were selected as the study subjects.The patients were randomly divided into study group and control group,with 33 cases in each group.The control group was treated withβreceptor blockers,and the study group was treated with statins on the basis of the control group.The treatment effects were compared between the two groups.Results:Before treatment,there was no significant difference in left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic diameter(LVESD)between the two groups(P>0.05).After treatment,LVEF in the two groups was higher than that before treatment,and the LVEF in the study group was higher than that in the control group,while the LVEDD and LVESD in the two groups were lower than those before treatment,and the LVEDD and LVESD in the study group were lower than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of interleukin-6(IL-6),hypersensitive C-reactive protein(hs-CRP)and tumor necrosis factor-α(TNF-α)between the two groups(P>0.05).After treatment,the levels of IL-6,hs-CRP and TNF-α in the two groups were lower than those before treatment,and the levels in the study group were lower than those in the control group,and the difference was statistically significant(P<0.05).The total effective rate of treatment in the study group was higher than that in the control group,and the difference was statistically significant(P=0.020).Conclusion:Statins combined withβreceptor blockers have significant effects in the treatment of chronic heart failure,which can improve cardiac function and reduce the levels of inflammatory factors.