抗血管内皮生长因子联合全视网膜激光光凝术治疗新生血管性青光眼的临床效果

Clinical Effect of Anti-Vascular Endothelial Growth Factor Combined with Panretinal Photocoagulation in Treatment of Neovascular Glaucoma

目的:分析抗血管内皮生长因子(VEGF)联合全视网膜激光光凝术(PRP)治疗新生血管性青光眼的临床效果。方法:选取2021年2月—2022年12月锦州医科大学附属第一医院眼科收治的85例新生血管性青光眼患者作为研究对象,根据随机数字表法分为对照组(n=42)及观察组(n=43)。对照组采用抗VEGF治疗,观察组在对照组基础上联合PRP。比较两组治疗效果。结果:治疗后6个月,两组视野缺损程度小于治疗前,且观察组小于对照组,两组视神经纤维层厚度大于治疗前,且观察组大于对照组,差异有统计学意义(P<0.05)。治疗后1周,两组眼压水平低于治疗前,差异有统计学意义(P<0.05);治疗后6个月,两组眼压水平低于治疗前,高于治疗后1周,观察组低于对照组,差异有统计学意义(P<0.05)。治疗后6个月,两组视力水平高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。两组并发症总发生率比较,差异无统计学意义(P>0.05)。结论:抗VEGF联合PRP治疗新生血管性青光眼的临床效果显著,可减小视野缺损程度,提高视神经纤维层厚度,改善眼压及视力水平,且安全性较好。

Objective:To analyze the clinical effect of anti-vascular endothelial growth factor(VEGF)combined with panretinal photocoagulation(PRP)in the treatment of neovascular glaucoma.Methods:A total of 85 patients with neovascular glaucoma admitted to Department of Ophthalmology,First Affiliated Hospital of Jinzhou Medical University from February 2021 to December 2022 were selected as the study subjects.They were divided into control group(n=42)and observation group(n=43)according to random number table method.The control group was treated with anti-VEGF,and the observation group was treated with PRP on the basis of the control group.The treatment effects were compared between the two groups.Results:At 6 months after treatment,the degree of visual field defect in the two groups was lower than that before treatment,and the degree in the observation group was lower than that in the control group,while the retinal nerve fiber layer thickness in the two groups was greater than that before treatment,and the thickness in the observation group was greater than that in the control group,and the difference was statistically significant(P<0.05).At 1 week after treatment,the intraocular pressure level in the two groups was lower than that before treatment,and the difference was statistically significant(P<0.05);At 6 months after treatment,the intraocular pressure level in the two groups was lower than that before treatment and higher than that at 1 week after treatment,the level in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).At 6 months after treatment,the visual acuity level in the two groups was higher than that before treatment,the level in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of complications between the two groups(P>0.05).Conclusion:The clinical effect of anti-VEGF combined with PRP in the treatment of neovascular glaucoma is significant,which can reduce the degree of visual field defect,increase the thickness of retinal nerve fiber layer,improve intraocular pressure and visual acuity,and have good safety.