盐酸氨溴索治疗慢性阻塞性肺疾病急性发作的效果分析

Effect Analysis of Ambroxol Hydrochloride in Treatment of Acute Episodes of Chronic Obstructive Pulmonary Disease

目的:分析盐酸氨溴索治疗慢性阻塞性肺疾病(COPD)急性发作的效果。方法:选取2021年6月—2022年6月宜兴市官林医院收治的COPD急性发作患者150例作为研究对象,依据随机数字表法分为两组,各75例。对照组采取常规治疗,观察组在对照组基础上应用盐酸氨溴索治疗。比较两组治疗效果。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.027)。治疗后,两组用力肺活量、第1秒用力呼气容积、呼气峰流速高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗后,两组二氧化碳分压(PaCO_(2))低于治疗前,血氧分压(PaO_(2))高于治疗前,且观察组PaCO_(2)低于对照组,PaO_(2)高于对照组,差异有统计学意义(P<0.05)。治疗后,两组呼吸困难量表、症状自我测试量表评分低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论:盐酸氨溴索治疗COPD急性发作的效果较好,可改善患者肺功能、血气指标,缓解临床症状,减轻呼吸困难症状。

Objective:To analyze the effect of ambroxol hydrochloride in treatment of acute episodes of chronic obstructive pulmo⁃nary disease(COPD).Methods:A total of 150 patients with acute episodes of COPD admitted to Yixing Guanlin Hospital from June 2021 to June 2022 were selected as the study subjects.They were divided into two groups according to the random number table method,with 75 cases in each group.The control group received conventional treatment,and the observation group received ambroxol hydrochloride treatment on the basis of the control group.The treatment effects of the two groups were compared.Re⁃sults:The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.027).After treatment,the forced vital capacity,forced expiratory volume in 1 second,and peak expira⁃tory flow rate in the two groups were higher than those before treatment,and these indexes in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the partial pressure of car⁃bon dioxide(PaCO_(2))in the two groups was lower than that before treatment,the partial pressure of oxygen(PaO_(2))in the two groups was higher lower than that before treatment,and the PaCO_(2) in the observation group was lower than that in the control group,the PaO_(2) in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Af⁃ter treatment,the scores of dyspnea scale and symptom self-test scale in the two groups were lower than those before treatment,the scores in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).Conclusion:Ambroxol hydrochloride has a good effect in the treatment of acute episodes of COPD,and can improve lung function and blood gas indexes of patients,alleviate clinical symptoms,and reduce the symptom of dyspnea.