溴莫尼定联合噻吗洛尔治疗青光眼的效果分析

Effect Analysis of Brimonidine Combined with Timolol in Treatment of Glaucoma

目的:分析溴莫尼定联合噻吗洛尔治疗青光眼的效果。方法:选取2022年4月—2023年4月常德市第一人民医院收治的82例青光眼患者作为研究对象,采用随机数字表法分为观察组和对照组,各41例。对照组采用噻吗洛尔治疗,观察组在对照组基础上联合溴莫尼定治疗。比较两组治疗效果。结果:治疗1周后,两组眼压低于治疗前,差异有统计学意义(P<0.05),但两组比较,差异无统计学意义(P=0.135);治疗后2、3、4周后,两组眼压低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P=0.026)。治疗后,两组睫状后动脉(PCA)和视网膜中央动脉(CRA)血管阻力指数低于治疗前,且观察组低于对照组,两组PCA和CRA收缩期峰值血流速度、舒张末期血流速度快于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组不良反应总发生率低于对照组,差异有统计学意义(P=0.034)。结论:溴莫尼定联合噻吗洛尔治疗青光眼的效果显著,能够降低眼压,改善眼底血流动力学,且不良反应发生率低。

Objective:To analyze the effect of brimonidine combined with timolol in the treatment of glaucoma.Methods:A total of 82 glaucoma patients admitted to the First People's Hospital of Changde City from April 2022 to April 2023 were selected as the study subjects.They were divided into the observation group and the control group using the random number table method,with 41 cases in each group.The control group was treated with timolol,and the observation group was treated with brimonidine on the basis of the control group.The treatment effect of the two groups was compared.Results:After 1 week of treatment,the intraocular pressure in the two groups was lower than that before treatment,and the difference was statistically significant(P<0.05),but there was no significant difference between the two groups(P=0.135);After 2,3 and 4 weeks of treatment,the intraocular pressure in the two groups was lower than that before treatment,and the intraocular pressure in the observation group was lower than that in the control group,with a statistically significant difference(P<0.05).The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.026).After treatment,the vascular resistance index of posterior ciliary artery(PCA)and central retinal artery(CRA)in the two groups was lower than that before treatment,and the index in the observation group was lower than that in the control group,while the peak systolic blood flow velocity and end-diastolic blood flow velocity of PCA and CRA in the two groups were faster than those before treatment,and the velocity in the observation group was higher than that in the control group,with a statistically significant difference(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P=0.034).Conclusion:The brimonidine combined with timolol has significant clinical efficacy in the treatment of glaucoma,and can reduce intraocular pressure,improve the fundus hemodynamics,and have a low incidence of adverse reactions.