早发型与晚发型子痫前期孕妇血清及胎盘中Gal-3、Gal-9水平变化及其临床意义

Changes of serum and placental levels of Gal-3 and Gal-9 in pregnant women with early-onset and late-onset preeclampsia and their clinical significance

目的研究早发型子痫前期(EOPE)与晚发型子痫前期(LOPE)孕妇血清及胎盘中半乳糖凝集素-3(Gal-3)半乳糖凝集素-9(Gal-9)表达水平变化及其临床意义。方法选取30例EOPE孕妇作为EOPE组,50例LOPE孕妇作为LOPE组;另随机选取40例同期健康孕妇作为对照组。比较三组血清及胎盘中Gal-3、Gal-9的表达情况。结果EOPE组和LOPE组血清和胎盘中Gal-3、Gal-9表达水平均显著高于对照组(P<0.05),且EOPE组血清和胎盘中Gal-3、Gal-9表达水平高于LOPE组(P<0.05)。结论Gal-3、Gal-9可能与PE的发生、发展相关,从而有助于了解PE的发病机制和临床诊疗。

Objective To study the expression levels of galectin-3(Gal-3)and galectin-9(Gal-9)in serum and placenta of pregnant women with early preeclampsia(EOPE)and late preeclampsia(LOPE)and their clinical significance.Methods 30 pregnant women with EOPE were selected as EOPE group and 50 pregnant women with LOPE were selected as LOPE group.Another 40 healthy pregnant women were randomly selected as control group.The expressions of Gal-3 and Gal-9 in serum and placenta were compared among the three groups.Results The expression levels of Gal-3 and Gal-9 in serum and placenta of EOPE group and LOPE group were significantly higher than those of control group(P<0.05),and the expression levels of Gal-3 and Gal-9 in serum and placenta of EOPE group were higher than those of LOPE group(P<0.05).Conclusion Gal-3 and Gal-9 may be related to the occurrence and development of PE,so as to help understand the pathogenesis and clinical diagnosis and treatment of PE.