影响子宫内膜癌患者术后放疗预后的相关因素研究

Study on the related factors affecting prognosis of patients with endometrial cancer after radiotherapy

目的 探讨影响子宫内膜癌患者术后放疗预后的相关因素。方法 选取87例子宫内膜癌术后放疗患者,根据患者预后情况分为预后不良组(25例)与预后良好组(62例),分析两组患者相关因素。结果 所有患者实施2年随访,预后不良组患者年龄、绝经状况、KPS评分、吸烟/饮酒、基础疾病、血红蛋白水平、临床分期及淋巴结转移与预后良好组比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示:影响子宫内膜癌术后放疗预后的危险因素是年龄≥70岁(OR=5.399)、淋巴结转移(OR=4.632)、临床Ⅲ~Ⅳ期(OR=4.259)、血红蛋白<100.00 g/L(OR=3.995)。结论 影响子宫内膜癌患者术后放疗预后的因素复杂,临床应实施针对性措施改善预后。

Objective To investigate the related factors affecting the prognosis of patients with endometrial cancer after radiotherapy.Methods 87 cases of patients with endometrial cancer were selected and divided into poor prognosis group(25 cases)and good prognosis group(62 cases)according to their prognosis.Results All patients were followed up for 2 years.There were statistically significant differences in age,menopause status,KPS score,smoking/drinking,underlying diseases,hemoglobin level,clinical stage and lymph node metastasis between the poor prognosis group and the good prognosis group(P<o.05).Multivariate Logistic regression analysis showed that the risk factors affecting the prognosis of postoperative radiotherapy for endometrial cancer were age≥70 years old(OR=5.399),lymph node metastasis(OR=4.632),clinical stage Ⅲ to Ⅳ(OR=4.259)and hemoglobin<100.00 g/L(OR=3.995).Conclusion The factors affecting prognosis of patients with endometrial cancer after radiotherapy are complex,and targeted measures should be taken to improve prognosis.