氟康唑联合克霉唑阴道片在霉菌性阴道炎治疗中的疗效评价

Evaluation of the therapeutic effect of fluconazole combined with clotrimazole vaginal tablets in the treatment of fungal vaginitis

目的分析氟康唑联合克霉唑阴道片治疗霉菌性阴道炎的临床效果。方法选取86例霉菌性阴道炎患者,根据治疗方法不同分为对照组与研究组,每组43例。对照组开展克霉唑阴道片治疗,研究组开展氟康唑联合克霉唑阴道片治疗。比较两组患者的治疗效果、不良反应发生情况、疾病症状消失时间及炎症因子指标。结果研究组患者治疗总有效率97.67%较对照组81.40%更高(P<0.05)。对照组不良反应发生率11.63%与研究组9.30%比较,差异无统计学意义(P>0.05)。研究组患者的外阴瘙痒、白带异常、腰腹酸痛、尿频、尿痛症状消失时间均较对照组更短(P<0.05)。治疗后,两组患者肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、白介素-4(IL-4)及白介素-6(IL-6)指标均较治疗前下降,且研究组患者较对照组更低(P<0.05)。结论氟康唑联合克霉唑阴道片应用于霉菌性阴道炎治疗中,可提升治疗效果,促进疾病症状消失,并改善患者的炎症因子,值得临床推广。

Objective To analyze the clinical efficacy of fluconazole combined with clotrimazole vaginal tablets in the treatment of fungal vaginitis.Methods 86 patients with fungal vaginitis were selected and divided into a control group and a study group based on different treatment methods,with 43 cases in each group.The control group received treatment with clotrimazole vaginal tablets,while the study group received treatment with fluconazole combined with clotrimazole vaginal tablets.Compare the treatment efficacy,incidence of adverse reactions,time of disappearance of disease symptoms,and inflammatory factor indicators between two groups of patients.Results The total effective rate of treatment in the study group was 97.67%,which was higher than that in the control group of 81.40%(P<0.05).The incidence of adverse reactions in the control group was 11.63%,and there was no statistically significant difference compared to the study group of 9.30%(P>0.05).The disappearance time of external genital itching,abnormal vaginal discharge,lower back and abdominal pain,frequent urination,and painful urination symptoms in the study group was shorter than that in the control group(P<0.05).After treatment,tumor necrosis factor was detected in both groups of patients-a(TNF-a)、Thelevelsofhigh-sensitivity C-reactiveprotein(hs-CRP),interleukin-4(IL-4),and interleukin-6(IL-6)decreased compared to before treatment,and the study group had lower levels compared to the control group(P<0.05).Conclusion The application of fluconazole combined with clotrimazole vaginal tablets in the treatment of fungal vaginitis can improve the treatment effect,promote the disappearance of disease symptoms,and improve the inflammatory indicators of patients,which is worthy of clinical promotion.