诱导细胞线粒体自噬化合物的研究进展

Research Progress of Compounds Inducing Cellular Mitophagy

自噬是一种特殊的程序性细胞死亡方式,维持着生物体内的重要代谢和能量平衡,该过程涉及降解蛋白质、细胞器等成分。线粒体自噬是一种高度选择性自噬,可通过降解多余或受损线粒体实现自身代谢物及能量需要。线粒体自噬作为如今选择性自噬中研究较多的领域,在疾病的发生发展中占有重要地位。研究发现一些化合物可通过不同的线粒体信号通路诱导细胞发生自噬,从而影响疾病的进程。作者描述了线粒体自噬的诱导机制,并就诱导细胞线粒体自噬化合物进行探讨,以期为开发靶向线粒体的治疗药物提供参考。

Autophagy is a kind of programmed cell death that maintains metabolic and energetic homeostasis in organisms,which involves degradation of proteins,organelles,and other components.Mitophagy is a highly selective autophagy,which achieves its own metabolites and energy requirements by degrading excess or damaged mitochondria.Mitophagy plays an important role in the development of diseases,as one of selective autophagy most studied up to now.Some compounds have been found to induce mitophagy in cells through different mitochondrial signaling pathways,affecting the disease.In the current review,we summarized the mechanism of mitophagy induction and compounds that induce mitophagy are summarized,with the aim to provide a reference for the research and development of new drugs targeting mitochondria.