血清和房水中抗氧化指标及炎症因子水平对不同分期糖尿病性白内障患者的临床意义

Clinical significance of antioxidant indexes and inflammatory factors in serum and aqueous humor in patients with diabetic cataract in different stages

目的探讨血清和房水中抗氧化指标、炎症因子水平对不同分期糖尿病性白内障患者的临床意义。方法回顾性选取2021年8月至2023年2月安徽医科大学附属滁州医院(滁州市第一人民医院)收治的180例眼病患者作为研究对象,依据眼病类型分为白内障组和眼外伤组,两组各90例。统计分析两组患者血清和房水中抗氧化指标[谷胱甘肽过氧化酶(GSH-Px)、过氧化氢酶(CAT)、超氧化物歧化酶(SOD)、总抗氧化能力(TAC)、一氧化氮]和炎症因子[超敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素(IL)-1β、IL-2]水平,并观察白内障组不同临床分期患者血清和房水中抗氧化指标、炎症因子水平。结果白内障组患者的血清和房水中GSH-Px、CAT、SOD、TAC水平均明显低于眼外伤组,血清和房水中一氧化氮水平明显高于眼外伤组,差异均有统计学意义(P<0.05)。白内障组患者血清和房水中hs-CRP、TNF-α、IL-1β水平均高于眼外伤组,血清和房水中IL-2水平均低于眼外伤组,差异均有统计学意义(P<0.05)。白内障组初始期、肿胀期、成熟期、过熟期患者血清和房水中GSH-Px、CAT、SOD、TAC水平随着分期的逐步进展均逐渐降低,血清和房水中一氧化氮水平逐渐升高,差异均有统计学意义(P<0.05)。白内障组初始期、肿胀期、成熟期、过熟期患者的血清和房水中hs-CRP、TNF-α、IL-1β水平随着分期的逐步进展均逐渐升高,血清和房水中IL-2水平逐渐降低,差异均有统计学意义(P<0.05)。结论血清和房水中抗氧化指标、炎症因子水平可为糖尿病性白内障患者病情分期提供依据。

Objective To explore the clinical significance of antioxidant indexes and inflammatory factors in serum and aqueous humor in patients with diabetic cataract in different stages.Methods A total of 180 patients with eye diseases admitted to Chuzhou Hospital Affiliated to Anhui Medical University,Chuzhou First People's Hospital from August 2021 to February 2023 were retrospectively selected as the study subjects,and they were divided into two groups:the cataract group and the ocular trauma group according to the type of eye disease,with 90 cases in each group.The levels of antioxidant indicators[glutathione peroxidase(GSH-Px),catalase(CAT),superoxide dismutase(SOD),total antioxidant capacity(TAC),nitric oxide],inflammatory factors[high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin(IL)-1β,IL-2]in the serum and aqueous humor of two groups of patients were statistically analyzed,and the levels of antioxidant indexes in serum and aqueous humor of the patients with different clinical stages in the cataract group were statistically analyzed.Results The levels of GSH-Px,CAT,SOD and TAC in serum and aqueous humor of cataract group were significantly lower than those of ocular trauma group,and the levels of nitric oxide in serum and aqueous humor were significantly higher than those in ocular trauma group,the differences were statistically significant(P<0.05).The levels of hs-CRP,TNF-αand IL-1βin serum and aqueous humor of cataract group were significantly higher than those of ocular injury group,and the levels of IL-2 in serum and aqueous humor were significantly lower than those of ocular injury group,the differences were statistically significant(P<0.05).In the cataract group,the levels of GSH-Px,CAT,SOD and TAC in serum and aqueous humor were gradually decreased,the level of nitric oxide in serum and aqueous humor were gradually increased,the differences were statistically significant(P<0.05).In the cataract group,the levels of hs-CRP,TNF-αand IL-1βin serum and aqueous humor were gradually increased,the levels of IL-2 in serum and aqueous humor were gradually decreased,the differences were statistically significant(P<0.05).Conclusion The antioxidant index and inflammatory factor levels in serum and aqueous humor can provide a basis for the staging of diabetic cataract patients.