D-二聚体监测在急性下肢深静脉血栓形成患者置管溶栓中疗效判断的意义

Significance of D-dimer Monitoring in Evaluating the Therapeutic Effect of Catheterization Thrombolysis in Patients with Acute Deep Venous Thrombosis of Lower Extremities

目的分析在急性下肢深静脉血栓形成患者置管溶栓中采取D-二聚体监测对疗效判断的意义。方法选取2021年1月—2022年12月在如东县中医院治疗的60例急性下肢深静脉血栓形成患者为研究对象,按照随机数表法分为对照组和观察组,每组30例。对照组实施足背静脉溶栓治疗,观察组实施置管溶栓治疗。对比两组D-二聚体指标、临床疗效。结果治疗后1~7 d,观察组D-二聚体指标水平依次为(68.14±2.13)、(70.71±2.29)、(75.76±2.01)、(71.58±2.37)、(61.24±2.22)、(52.21±2.56)、(28.22±2.01)mg/L,均比对照组更高,差异有统计学意义(t=66.211、48.766、49.042、49.693、58.197、40.223、13.706,P均<0.05)。治疗后第8天,两组D-二聚体指标水平对比,差异无统计学意义(P>0.05)。观察组治疗后静脉通畅评分[(4.63±1.42)分]比对照组更低,静脉通畅率[(62.98±14.26)%]比对照组更高,差异有统计学意义(P均<0.05)。结论采用D-二聚体监测方式,能够较为准确评估急性下肢深静脉血栓患者置管溶栓的疗效。

Objective To analyze the significance of D-dimer monitoring in the evaluation of therapeutic effect of catheterization thrombolysis in patients with acute lower extremity deep venous thrombosis.Methods From January 2021 to December 2022,60 patients with acute lower extremity deep venous thrombosis treated in Rudong County Hospital of Traditional Chinese Medicine were selected as the research objects.According to the random number table method,they were divided into control group and observation group,with 30 cases in each group.The control group was treated with dorsal vein thrombolysis,and the observation group was treated with catheterization thrombolysis.The D-dimer index and clinical efficacy were compared between two groups.Results From 1 to 7 days after treatment,The D-dimer indexes in the observation group were(68.14±2.13),(70.71±2.29),(75.76±2.01),(71.58±2.37),(61.24±2.22),(52.21±2.56),(28.22±2.01)mg/L,which were all higher than those of the control group,and the differences were statis⁃tically significant(t=66.211,48.766,49.042,49.693,58.197,40.223,13.706,all P<0.05).On the 8 th day after treat⁃ment,there was no statistically significant difference in the level of D-dimer between the two groups(P>0.05).After the treatment,the score of venous patency[(4.63±1.42)points]in the observation group was lower than that in the con⁃trol group,and the rate of venous patency[(62.98±14.26)%]was higher than that in the control group,the differences were statistically significant(both P<0.05).Conclusion The D-dimer monitoring method can accurately evaluate the efficacy of catheterization thrombolysis in patients with acute deep venous thrombosis of lower extremities.