烯丙雌醇片与地屈孕酮片联合治疗先兆流产对患者症状缓解时间、血清孕酮及β-HCG水平的影响

Effects of Allylestradiol Tablets and Dydrogesterone Tablets on Symptom Remission Time,Serum Progesterone andβ-HCG Levels in Patients with Threatened Abortion

目的探讨烯丙雌醇片与地屈孕酮片联合治疗先兆流产对患者症状缓解时间、血清孕酮及人绒毛膜促性腺激素(β-humanchorionicgonadotrophin,β-HCG)水平的影响。方法选取2021年3月—2023年4月武威市人民医院诊治的120例先兆流产患者为研究对象,按照随机数表法分为对照组和观察组,每组60例。对照组口服地屈孕酮片治疗,观察组在对照组基础上加用烯丙雌醇片治疗。对比两组患者的症状缓解时间、血清性激素指标、不良反应。结果观察组腹痛缓解时间(3.44±1.12)d、腰酸缓解时间(4.01±0.96)d、出血停止时间(3.89±1.68)d均短于对照组(5.41±1.29)d、(6.17±1.24)d、(6.39±2.47)d,差异有统计学意义(P均<0.05)。治疗后,观察组的孕酮、β-HCG、雌二醇水平均高于对照组,差异有统计学意义(P均<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论在先兆流产患者中应用烯丙雌醇片联合地屈孕酮片治疗效果显著,能够促进患者机体内血清性激素水平改善,缩短症状缓解时间,且安全可靠。

Objective To investigate the effects of allylestradiol tablets and dydrogesterone tablets on symptom remis⁃sion time,serum progesterone andβ-human chorionic gonadotrophin(β-HCG)levels in patients with threatened abor⁃tion.Methods A total of 120 patients with threatened abortion diagnosed and treated in Wuwei City People's Hospital from March 2021 to April 2023 were selected as the study objects and divided into control group and observation group according to random number table method,with 60 cases in each group.The control group was treated with dy⁃drogesterone tablets,and the observation group was treated with allylestradiol tablets on the basis of control group.Symptom remission time,serum sex hormone indexes and adverse reactions were compared between the two groups of patients.Results Abdominal pain relief time(3.44±1.12)d,lumbar acid relief time(4.01±0.96)d and bleeding cessa⁃tion time(3.89±1.68)d in the observation group were shorter than those in the control group(5.41±1.29)d,(6.17±1.24)d and(6.39±2.47)d,and the differences were statistically significant(all P<0.05).After treatment,the levels of progesterone,β-HCG and estradiol in the observation group were higher than those in the control group,and the dif⁃ferences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reac⁃tions between the two groups(P>0.05).Conclusion In patients with threatened abortion,the application of allylestradiol tablets combined with dydrogesterone tablets has significant therapeutic effect,can promote the improvement of serum sex hormone levels in patients,shorten the time of symptom relief,and is safe and reliable.